Should depression be treated with excitatory or inhibitory medications? Normally I have seen inhibitory drugs being prescribed for depression, hence my question.
Indeed most medication types of Antidepressants are inhibitory such as Selective serotonin reuptake inhibitors, Serotonin–norepinephrine reuptake inhibitors, Norepinephrine reuptake inhibitors, and Norepinephrine–dopamine reuptake inhibitors, etc.
However, surprisingly some research shows deprivation of REM sleep may at least temporarily improve depression. Thus if you count deprivation of sleep as "excitatory" generally in your dictionary then this could be such a case, albeit it's not the scientific sense as excitatory synapse defined in terms of increased probability of an action potential occurring in a subsequent postsynaptic cell or excitatory neurotransmitter molecules.
It has been suggested that acute REM sleep deprivation can improve certain types of depression—when depression appears to be related to an imbalance of certain neurotransmitters. Although sleep deprivation in general annoys most of the population, it has repeatedly been shown to alleviate depression, albeit temporarily. More than half the individuals who experience this relief report it to be rendered ineffective after sleeping the following night. Thus, researchers have devised methods such as altering the sleep schedule for a span of days following a REM deprivation period and combining sleep-schedule alterations with pharmacotherapy to prolong this effect. Antidepressants (including selective serotonin reuptake inhibitors, tricyclics, and monoamine oxidase inhibitors) and stimulants (such as amphetamine, methylphenidate and cocaine) interfere with REM sleep by stimulating the monoamine neurotransmitters which must be suppressed for REM sleep to occur. Administered at therapeutic doses, these drugs may stop REM sleep entirely for weeks or months.