This is not my research field, but I'm also very interested in this topic. As far as I know there has not been much research done but two articles of interest are:
Washburn, D. A. (2003). The games psychologists play (and the data they provide).The games psychologists play (and the data they provide). Behavior research methods, instruments & computers, 35(2), 185-193. Psychonomic Society Publications.
This is a (rather old) review article of how computer games have been used in psychological research.
Frey, A., Hartig, J., Ketzel, A., Zinkernagel, A., & Moosbrugger, H. (2007). The use of virtual environments based on a modification of the computer game Quake III Arena® in psychological experimenting. The use of virtual environments based on a modification of the computer game Quake III Arena® in psychological experimenting. Computers in Human Behavior, 23(4), 2026-2039.
This is a study where they used a modified version of the Quake III engine to look at a quite diverse set of variables. I find the use of Quake III to investigate navigation behavior the most interesting part of the study.