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10 votes
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Can the effectiveness of antidepressants be explained by a placebo effect?

Short answer Don't believe everything you read. Background The article cited (Kirsch, 2014) appears in a German journal with a mediocre impact factor. Not the most convincing platform. I'll cite ...
AliceD's user avatar
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5 votes
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How can someone enjoy something without dopamine?

It is oversimplifying things that a single compound mediates complex human behavior. To nuance things a bit, there are more neurotransmitters and modulators that mediate feelings of pleasure, as you ...
AliceD's user avatar
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3 votes
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Why might sleeping on the floor alleviate PTSD symptoms?

Why might sleeping on the floor alleviate PTSD symptoms? Question: Does sleeping on the floor have similar neurotransmitter effects, as sleeping under a weighted blanket might? Psychiatrically, would ...
Rob's user avatar
  • 311
3 votes
Accepted

Measuring serotonin in the brain with a sample of spinal fluid

It is entirely possible to sample serotonin levels from cerebral spinal fluid (CFS) taken via a lumbar puncture, also known as a spinal tap, to the spinal column from the central nervous system (CNS). ...
Comte's user avatar
  • 1,196
3 votes

How does acute tryptophan depletion work?

don't the neurons already have plenty of serotonin stored in the axon vesicles from which the neurotransmission happens Sure, but neurotransmission is happening all the time. It's not uncommon for a ...
Bryan Krause's user avatar
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2 votes
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What is meant by "serotonergic" in "serotonergic psychedelics"

Short answer It's messy. Background The classical psychedelics (mescaline, DMT etc.) are derived from plants (peyote, ayahuasca) and have a long history of use by shamans and originally often mainly ...
AliceD's user avatar
  • 20.6k
2 votes

Causality regarding neurotransmitter imbalance and depression

I have what is mostly a frame-challenge to your question as an answer: the simple "neurotransmitter imbalance" hypothesis is a bit outdated, and it hasn't been strongly influential in a research ...
Bryan Krause's user avatar
  • 7,376
2 votes

Can Prozac cause anxiety?

Prozac (the generic drug fluoxetine) is a selective serotonin reuptake inhibitor (SSRI) and is primarily prescribed as an antidepressant, but also as an anxiolytic. The side effects of fluoxetine ...
AliceD's user avatar
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2 votes

Can the effectiveness of antidepressants be explained by a placebo effect?

Let me supplement Alice's nice answer with a few more points. Regarding there are antidepressants that do not enhance serotonin but suppress it. That seems to be tianeptine; it is often brought ...
the gods from engineering's user avatar
2 votes

Relation of serotonin level and mood/depression

You say that Antidepressants [a]rise [the] amount of serotonin in blood in short period of time. However, you should take antidepressants for quite a long period of time so that it took effect. Up to ...
the gods from engineering's user avatar
1 vote
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How do SSRIs interact with MDMA?

Do SSRIs interfere with MDMA? Yes, a 2022 systematic review by Saparast et al found that SSRIs and duloxetine attenuated the subjective effects of MDMA. Do they both bind to SERT? Yes, but they act ...
Malcolm Forbes's user avatar
1 vote

are serotonin levels higher or lower in dominant vs. non-dominant primates and humans?

It seems Maté simply misread the research that he cited. The study on this, from 1984, says that Dominant male adult vervet monkeys have whole-blood serotonin concentrations approximately twice ...
xdavidliu's user avatar
  • 165

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