Questions tagged [serotonin]

For questions about the neurotransmitter serotonin's role in behavior and cognition.

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Does 5HT neccessarily desensitize at long term use of SSRIs?

I have a knowledge gap which I can't find many papers about. I know that receptors like 5HT desensitize when a prolonged increased1 availability is present because the brain tries to maintain ...
Moritz Roessler's user avatar
3 votes
1 answer
171 views

How do SSRIs interact with MDMA?

I'm not sure if I understand the synergetic effects of MDMA and SSRIs correctly. According to PMC81503 "It is clear, however, that the increase in the net release of serotonin (and possibly ...
Moritz Roessler's user avatar
2 votes
0 answers
21 views

Does dopamine suppress serotonin production?

In a youtube video in spanish, I heard that dopamine suppress serotonin production. Is that true?
Dare to ask-I dnt mind punishm's user avatar
6 votes
1 answer
220 views

How can someone enjoy something without dopamine?

In this video, Andrew Huberman says people and even animals with depleted dopamine levels can still enjoy stuff. How does one enjoy without dopamine? Isn't it the pleasure chemical? Can serotonin, ...
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3 votes
1 answer
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How does acute tryptophan depletion work?

The literature online about this practice is very poor. The theory goes like this: A mix of amino acids that does not include tryptophan will lower the proportion of tryptophan in the bloodstream. ...
JClaussFTW's user avatar
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What are the pharmacodynamics (Ki nM) of the monoamine neurotransmitters?

Ok, so any psychoactive drug will have different affinities for different receptor types. For instance, sertraline has an extreme affinity for the SERT and very little affinity for the 5-HT1A receptor....
JClaussFTW's user avatar
5 votes
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Any statistics on the likelihood of, consumption frequencies and dosages required for serotonin syndrome to occur with LSD?

This may be too obscure of a question to have sufficient, if any, statistics on it. If that's the case, any relevant information is appreciated. From what I've gathered, very high doses and/or very ...
A. Kvåle's user avatar
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1 answer
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Non-serotonergic hallucinogens

According to this article, agonism of the 5-HT$_{2A}$ is necessary for hallucinogenesis. Now, not all hallucinogens are primarily serotonergic, but does there exist hallucinogens that aren't at all ...
A. Kvåle's user avatar
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1 vote
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What is meant by "serotonergic" in "serotonergic psychedelics"

"Serotonergic psychedelics" is apparently a sub-class of psychedelics. Now, I believed that the pharmacological definition of psychedelics is that they all agonise 5HT receptors, especially ...
A. Kvåle's user avatar
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How do psychedelics work? [duplicate]

I realize my question is more of a pharmacological one than a neuroscientific one, but I didn't know where else to ask this question. As far as I've read, there's two components to how psychedelics ...
A. Kvåle's user avatar
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Measuring serotonin in the brain with a sample of spinal fluid

Is it possible to measure serotonin with a sample of spinal fluid?
CSD's user avatar
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2 votes
1 answer
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Causality regarding neurotransmitter imbalance and depression

Neurotransmitter imbalances are blamed for various psychiatric conditions (depression, ADHD, etc). Clearly plasma levels of neurotransmitters are confirmed to be abnormal in some people with such ...
SchroedingersCat's user avatar
2 votes
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What determines whether a monoamine neurotransmitter is recycled or broken down by MAO?

When a neurotransmitter detaches from the receptor and is returned to the neuron via the transporter, what are the primary factors that influence whether that molecule is re-stored in a vesicle by ...
JClaussFTW's user avatar
1 vote
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42 views

How does the body respond to having excess levels of neuronal, not synaptic, serotonin?

If a person consumes large amounts of 5-HTP or SAM-e resulting in elevated serotonin levels in their synaptic vesicles, how is this excess offloaded? What is the average rate of clearance? All the ...
JClaussFTW's user avatar
4 votes
1 answer
143 views

What can happen if a human takes SB-243213?

SB-243213 acts as a selective inverse agonist for the 5-HT2C receptor. The 5-HT2C receptor is one of many 5-HT receptors which are receptors that bind serotonin, and seems to play a major role in ...
SB-243213fan's user avatar
1 vote
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546 views

Why does venlafaxine have lower incidence of sexual dysfunctions at higher doses?

Venlafaxine at low dosages strongly inhibits serotonin, at moderate dosages also norepinephrine and only high dosages it also inhibits dopamine. The ratio is the following. serotonin : ...
Slazer's user avatar
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Since we know the 5ht2a receptor impacts learning efficiency why has stimulating it not been tried for alleviating learning disabilities?

If you go on wikipedia or do a search on Google you can quickly find a bunch of articles on the importance of serotonin for impacting the efficacy of learning. Experiments have been run in mice for ...
ZeroPhase's user avatar
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Why might sleeping on the floor alleviate PTSD symptoms?

Question: Does sleeping on the floor have similar neurotransmitter effects, as sleeping under a weighted blanket might? Psychiatrically, would it be expected that a person having PTSD would find ...
elika kohen's user avatar
2 votes
0 answers
45 views

Lowering people's serotonin levels does not change their mood?

I'm starting to pick off sub-topics from this omnibus question, which I think it's too broad to answer properly/directly in the SE format. So, let's start with one of the claims there: Lowering ...
the gods from engineering's user avatar
1 vote
1 answer
179 views

Relation of serotonin level and mood/depression

Not a biologist. Not even related to science, however I read a lot of popular psychology stuff, plus read some info about antidepressants and a question tortures me :) Antidepressants arise amount of ...
Victor's user avatar
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5 votes
1 answer
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are serotonin levels higher or lower in dominant vs. non-dominant primates and humans?

On page 242 of The Moral Animal, Robert Wright states that In vervet monkey societies, dominant males have more of the neurotransmitter serotonin than do their subordinates. And one study found ...
xdavidliu's user avatar
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What causes passion, psychologically and chemically, and how does it last? [closed]

I recently finished reading "Habits of a happy brain", which discusses the role of oxytocin, serotonin, endorphin, dopamine, and cortisol in seeking behavior. The book argues that we evolved to ...
user1999728's user avatar
3 votes
0 answers
55 views

Is there any evidence that better sleep reduces the symptoms of chronic severe Fibromyalgia?

Is there any evidence that better sleep reduces the symptoms of chronic severe Fibromyalgia? Severe fibromyalgia has been linked to the possible depletion of serotonin through prolonged and ...
Damien's user avatar
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1 vote
1 answer
118 views

Can Prozac cause anxiety?

I know some selective serotonin inhibitors, such as Prozac, are prescribed for anxiety, but can they also cause anxiety?
user379468's user avatar
7 votes
2 answers
540 views

Can the effectiveness of antidepressants be explained by a placebo effect?

A friend of mine showed me a paper (Kirsch, 2014) where the author claims that antidepressants work mostly through a placebo effect (backed up with relevant citations). Antidepressants are generally ...
Janus Boffin's user avatar
3 votes
1 answer
155 views

Epigenetics and serotonin (amygdala threat response)?

In this article it states that: Increased promoter methylation of the serotonin transporter gene predicted increased threat related amygdala activity. I'm finding this somewhat difficult to ...
Meep's user avatar
  • 425
10 votes
3 answers
933 views

Are there any ways to increase dopamine and serotonin levels when working or learning something complex?

There is much information regarding learning styles and ways to leverage them, along with boosting focus, alertness and concentration. However, I'm looking for accompanying information that would be ...
Greg McNulty's user avatar
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5 votes
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Is movement/activity level related to serotonin availability or reuptake rates in the brain?

I'm aware of this research article that explores the relationship between motion and serotonin systems: 5-HT and motor control: a hypothesis. Based on the article above, it seems to me that a "very ...
Alex Stone's user avatar
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