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As far as I know, this effect cannot be eliminated by any practical means, other than stratifying the subjects into groups according to type of drug, dosage, duration of use etc. and use statistical testing to look for any differences between the groups with, e.g., linear mixed modeling. However, a cursory search on Google Scholar yields multiple studies ...


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Predicting individual side effects is generally not feasible in current clinical practice, although in the purview of "personalized medicine", mostly as a research goal/topic. For psychotropic medications, this is largely envisaged to work through pharmacogenomics: In pharmacogenomics, genomic information is used to study individual responses to ...


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Anticholinergics by themselves commonly have sedative effects. The reason you read about benztropine being used is that it has dopaminergic activity as well (in addition to anticholinergic activity). Specifically, benztropine and its derivatives are also dopamine reuptake inhibitors. So from the perspective that benztropine is a dopamine reuptake inhibitor, ...


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Therapeutic effects and adverse reactions of psychoneuro-pharmaceutical drugs are tested using the same gold standard as usd for more conventional drugs, namely in randomized controlled trials. Phase I trials focus on side effects and dosages in a small group of healthy subjects. Phase II testings assess efficacy and side effects in a medium-sized ...


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How can we earnestly predict the effects, both therapeutic and adverse, of psychotropic drugs on the specific patient in front of us? The basic answer is that you cannot necessarily predict accurately how any medication will affect any individual person. Medications can in general, carry risks of side effects. The risk levels of each side effect will also ...


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triptans could help boost the efficacy of SSRIs There is minimal evidence for this Chris. One of the reasons for that is that there is a limit to how much serotonin is released for the nerve cell. So more of the same isn't going to make much difference. edit: So in terms of reuptake inhibitors, triptans are agonists. So increased agonism seems unlikely to ...


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