3 votes
Accepted

Are inhibitory synapses governed by different chemicals than excitatory synapses?

Short answer I cannot give a conclusive answer, but if you are talking about a schoolbook neuron with different neurons synapsing onto it, then excitation is indeed generally mediated by another ...
AliceD's user avatar
  • 20.6k
3 votes

How does acute tryptophan depletion work?

don't the neurons already have plenty of serotonin stored in the axon vesicles from which the neurotransmission happens Sure, but neurotransmission is happening all the time. It's not uncommon for a ...
Bryan Krause's user avatar
  • 7,376
3 votes
Accepted

How can the action of drugs be determined by so few neurotransmitters?

The brief answer to your question is that: Serotonin to be clear is not a primary neurotransmitter, as it is not a primary driver or inhibitor of action potential generation --- the core signal by ...
Doc of the Mind's user avatar
3 votes

What causes dopamine in our body

Allow me to extend a more empathetic answer; stack exchange is great, but the rigid responses are sometimes hard to stomach. Dopamine is a neurotransmitter that basically works as a messenger ...
James Jimenez's user avatar
2 votes

Is the amount of learning modulated by reward transmitters?

A bit of context In mammalian brains, a main neurotransmiter linked with reward is Dopamine. This molecule is produced in the Ventral Tegmental Area (VTA) and in the Substantia Nigra (SN). In a very ...
Hornycar's user avatar
2 votes

Is the amount of learning modulated by reward transmitters?

The effect of dopamine signaling is one of the areas where computational neuroscience has provided insight into brain mechanisms, specifically via Reinforcement Learning (RL) models. Based off this ...
Seanny123's user avatar
  • 8,853
2 votes

What causes dopamine in our body

The way that you are describing dopamine fundamentally misunderstands how neurotransmitters work. It makes sense to talk about hormones as elevated or reduced above a baseline level. This does not ...
stjep's user avatar
  • 128
2 votes
Accepted

Are there specific neurotransmitters for specific sensations?

No. For example, the neurotransmitter at the first stage of auditory processing (the inner hair cell VII cranial nerve synapse) and visual processing (rod and cone synapses with a bipolar cells) is ...
StrongBad's user avatar
  • 2,633
2 votes

Do psychiatrists and researchers themselves don't have an idea how antidepressants work?

Haha, yep. We don't know how depression or SSRIs work. We have hypotheses for both schizophrenia and depression - the dopamine hypothesis and the serotonin hypothesis. While I was conducting my ...
Opp3nh31m3r's user avatar
2 votes

Is Dr. Russo’s “endocannabinoid deficiency” a valid theory?

I'd say it is a low-impact theory. The original (2004) paper in which this was proposed has around 60 citations in Google Scholar. That's pretty low for a paper like this (if the theory were ...
the gods from engineering's user avatar
2 votes

Aesthetic pleasure hormone or neurotransmitter

μ-opioid receptors (MOR) have been demonstrated to be involved in our perception of beautiful faces (https://www.medicaldaily.com/seeing-pretty-faces-rewards-brain-perceiving-beauty-all-chemical-...
Carla's user avatar
  • 23
2 votes

Causality regarding neurotransmitter imbalance and depression

I have what is mostly a frame-challenge to your question as an answer: the simple "neurotransmitter imbalance" hypothesis is a bit outdated, and it hasn't been strongly influential in a research ...
Bryan Krause's user avatar
  • 7,376
1 vote
Accepted

How do SSRIs interact with MDMA?

Do SSRIs interfere with MDMA? Yes, a 2022 systematic review by Saparast et al found that SSRIs and duloxetine attenuated the subjective effects of MDMA. Do they both bind to SERT? Yes, but they act ...
Malcolm Forbes's user avatar
1 vote

Are all synapses "gappy", and what exactly is in the gap?

See a previous Q&A: How synapses are hold in place if they're not phisically attached? Synapses are quite structured, and there are physical connections between pre- and post-synapse through ...
Bryan Krause's user avatar
  • 7,376
1 vote

Why do SSRIs take multiple weeks to reach their full effect?

Short answer The delayed effect of serotonin-specific reuptake inhibitors can be explained, at least in part, because of their actions on the downregulation of presynaptic 5HT1A receptors. Background ...
AliceD's user avatar
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1 vote
Accepted

Does consumption of amino acid supplements improve human executive function and self-regulation in ADHD cases?

There's a recent negative study: Bergwerff et al. (2016) "No Tryptophan, Tyrosine and Phenylalanine Abnormalities in Children with Attention-Deficit/Hyperactivity Disorder": This study is the ...
the gods from engineering's user avatar
1 vote
Accepted

How do neurons know where to send transmitters?

When a neuron fires an action potential, it doesn't "select" a target. It releases neurotransmitter (somewhat probabilistically, as vesicle release has a probability <1 at most synapses) ...
Bryan Krause's user avatar
  • 7,376
1 vote
Accepted

Is there a mechanical/vibrational communication method between pre- and post-synaptic terminals in addition to chemical and electrical synapses?

Short answer Action potentials travelling through the axon are accompanied by a mechanical displacement of the axonal membrane. Background Multiple studies have shown that a mechanical displacement of ...
AliceD's user avatar
  • 20.6k
1 vote

Neurotransmitters by neuron types

Wikipedia has a comprehensive list of neurotransmitters, categorized as (a short list): Amino acids: glutamate, aspartate, D-serine, γ-aminobutyric acid (GABA), glycine Gasotransmitters: nitric oxide ...
Jan's user avatar
  • 454
1 vote

Triptans and SSRIs

triptans could help boost the efficacy of SSRIs There is minimal evidence for this Chris. One of the reasons for that is that there is a limit to how much serotonin is released for the nerve cell. ...
Poidah's user avatar
  • 1,019
1 vote
Accepted

Why seemingly all the neuronal membrane-bound receptor are exclusively GPCR or highly homologous to GPCR family?

I think you're confused about proteins that are GPCRs versus having homology. GABA-B is another that is a GPCR (it is not particularly related to GABA-A). These are also called metabotropic receptors. ...
Bryan Krause's user avatar
  • 7,376
1 vote
Accepted

Does the act of neural-repair fire off neurons?

Question: Does neural repair result in firing neurons? This is a difficult question. Because a repair occurs when and where there is a damage. If there are abnormal firings of neurons, it will be ...
user287279's user avatar
  • 1,825
1 vote

experimental tracking and treating bipolar disorder

I am not from a pure field of neuroscience so I did a bit of research. (Part put in bold by me is the bit which pertains to Bipolar Disorder (BPD)) Simon N Young of McGill University in Montréal, ...
Chris Rogers's user avatar
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