4 votes

How does one add a commutator to the UCLA miniscope cable?

I'm one of the developers of the Miniscope. We have been very happy with #FL-2-C from dragonfly. This commutator is very low torque and we have never had an issue with sending power or data through it....
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4 votes
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Converting human's memory into digital data

I am wondering whether converting someone's memory into digital data is possible or not. Not today, but it is an active area of research. One non-profit foundation, headed by computational ...
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  • 311
3 votes

How does one add a commutator to the UCLA miniscope cable?

We have found CRJ-05 to work fine for rats. It requires a bit of starting torque (~0.4N*cm), so may not work for mice. It is designed for high frequency coax communication though. The quote we ...
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  • 1,855
3 votes

Can a brain dead person be revived through a modified defribillator?

Brain death is defined as the complete and permanent loss of brain function (1), or complete, irreversible cessation of brain function (2), or irreversible cessation of all functions of the whole ...
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  • 1,795
3 votes

How does acute tryptophan depletion work?

don't the neurons already have plenty of serotonin stored in the axon vesicles from which the neurotransmission happens Sure, but neurotransmission is happening all the time. It's not uncommon for a ...
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  • 6,174
3 votes

Simultaneous extracellular recording from different distant sites (in rodents)

I wouldn't know why multi-site cortical extracellular recordings would not be feasible? What would the practical experimental or technical limitation be in your opinion? As long as you have a ...
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2 votes
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Where can I find the connectivity matrix of the connectome of C. Elegans?

The full connectome of C. elegans (Fig. 1.) is described by Farber (2012) and as far as I know, the most complete data on C. elegans, including its connectome is available from the OpenWorm Project ...
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2 votes

How to record mouse-pointer fixations?

I think the key term here is dwell time. There is abundant literature on this. For example, Sample et al. (2008), go into quite some detail as to how to calculate this. In a nutshell, it basically ...
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2 votes

At what impedances should one gold plate 12.5-µm diameter nichrome wire tetrodes for targeting different brain areas?

The ideal impedance of any electrode aimed at recording low-amplitude neural signals (barred suction glass-pipette electrodes for patch clamping) is simply: as low as possible. In case of tetrodes, i....
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2 votes

How does one add a commutator to the UCLA miniscope cable?

I haven't seen any either. But what I do know is that there is a wireless version coming out. It Might make sense to wait for one since commutators tend to be expensive.
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2 votes

How does one add a commutator to the UCLA miniscope cable?

NeuroTek Inc (neurotek.ca) specializes in motorized commutators and is in the process of building a commutator to handle digital and analog. Specifically it is being built for mini microscopes and ...
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  • 21
2 votes

Good neuroscience research blogs

I would also like to plug Markus Meister’s blog: https://markusmeister.com Jeremy Borniger’s blog and journal club: https://jeremyborniger.com/new-blog The Spike on Medium curated by Mark ...
2 votes

Good neuroscience research blogs

Also check: https://bitsandbrains.io/ https://www.talyarkoni.org/blog/ calling it a blog is too much but sometimes we share stuff: kordinglab.com But also, there is maybe a bit more of a culture of ...
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Differences in reaction time on visual tasks with and without binocular disparity ques?

According to these three published studies I found below - reaction time is slower when depth disparity information is withheld, as to whether or not that extra information is actually encoded in the ...
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  • 409
2 votes
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In an experiment with animated stimuli, should I accept answers during Animation Time and count it into the Response Time?

You could solve this problem telling your participant that they have to answer as soon as they spot the right answer or if you do not want them to answer before the end of the stimuli you can disable ...
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  • 157
2 votes

How to determine nerve conduction velocity?

I think there are many ways to accomplish this in terms of technical detail, but they will all boil down to measuring the arrival of an action potential along the axon on at least two points with ...
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1 vote

Why do we understand so little about the brain?

"does neuroscience have to be completely re-hauled and restructured (...)?" I would leave aside the (over) exaggeration that "We have no clue how any of these things work", and ...
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  • 133
1 vote
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Mismatch negativity vs. mismatch response

MMN/MMR refer to responses during an oddball paradigm. The typical arrangement of this sort of paradigm is to have a sequence of stimuli, for example, a sequence of tones of one frequency, followed by ...
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  • 6,174
1 vote
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Constraints on dataset size for AI-assisted connectome reconstruction

Improving labeling Increasing the amount of data that humans can annotate in a reasonable amount of time (your second question), one essentially needs to develop better labeling tools. Typically, ...
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1 vote

Converting human's memory into digital data

Rob's answer is good: lots of detail on current research. What is meant by memory? Nearly all of the operations of the brain are based on or involve retrieving previous states of physiology or ...
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1 vote

experimental tracking and treating bipolar disorder

I am not from a pure field of neuroscience so I did a bit of research. (Part put in bold by me is the bit which pertains to Bipolar Disorder (BPD)) Simon N Young of McGill University in Montréal, ...
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1 vote
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Which possible methods can be used to determine if a certain part of the brain is active?

PET (positron emission tomography) will measure glucose consumption, e.g. https://www.ncbi.nlm.nih.gov/pubmed/2147116 fMRI will measure changes in blood flow, or more precisely measuring the blood-...
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  • 9,915
1 vote

How to stain for orexin neurons in mice?

Let's work backwards. I don't currently have access to means to use transgenic orexin knockout mice as are mentioned in the article by Tsujino & Sakurai (though if anyone's used them before I'd ...
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  • 1,227
1 vote
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Does the peripheral nervous system processes information like central neurons do?

Short answer Peripheral nerves can be stimulated by, e.g., electrical pulses and their responses can be recorded back by using recording electrodes. Peripheral nerves generally do not process the ...
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