Questions tagged [drugs]

For questions that deal with substances injected or ingested into the body for various physiological or psychological effects.

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How does THC tolerance work and how does this impact psychotic effects of THC?

I am interested in knowledge about the inner workings of THC tolerance. I have no direct sources, but know several (n = 7) individuals who say they build up a tolerance at chronic consumption and lose ...
Moritz Roessler's user avatar
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Does 5HT neccessarily desensitize at long term use of SSRIs?

I have a knowledge gap which I can't find many papers about. I know that receptors like 5HT desensitize when a prolonged increased1 availability is present because the brain tries to maintain ...
Moritz Roessler's user avatar
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Do psychiatrists take into account affects on the different serotonin receptor types and subtypes when cycling anti-depressants in patients?

If someone is going through SSRIs to find one that works, doesn't it make sense to target each receptor in turn rather than the same one with different drugs (like prozac and zoloft, for example)? Is ...
James Scholl's user avatar
3 votes
1 answer
159 views

How do SSRIs interact with MDMA?

I'm not sure if I understand the synergetic effects of MDMA and SSRIs correctly. According to PMC81503 "It is clear, however, that the increase in the net release of serotonin (and possibly ...
Moritz Roessler's user avatar
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Would it be possible to directly block dopamine release in the mesolimbic area?

Thinking about the treatment of (drug induced) psychosis I'm having the following thoughts. Drug induced psychosis makes up for 25% - 50% of cases of patients experiencing psychosis . Nevertheless ...
Moritz Roessler's user avatar
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Effects of Methamphetamine

When I walk downtown in Seattle, I often see individuals who appear to be "high" on various substances, "crouched" down(bent over) and rocking back and forth. I asked about this ...
I_throw_but_dont_catch's user avatar
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Can disease, drugs, or other physiological conditions violate the all-or-none rule for action potential?

We are taught that the amplitude of a neuron's spike is always the same (within a negligibly small range)--all or none. But it seems that anomalous physiological conditions like certain diseases or ...
Anasker's user avatar
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Is there good evidence that long-term stimulant usage in children has no harmful effect when stopped?

Essentially, I am looking for an RCT done on children, where they went on a stimulant drug for at least 3 years, and then stopped administering the drug. What I'm worried about is long-term lower ...
solomon alon's user avatar
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Caffeine modulating substances in coffee

From personal experimentation I know that caffeine affects me differently than coffee. Are there any known caffeine modulating substances found in coffee?
CuriousIndeed's user avatar
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2 answers
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Are there methods of evaluating the effects of psychoactive drugs that use free-form verbal reports?

If one wished to study the effects of a psychoactive drug such as LSD, what strikes me as a natural primary starting point would be to ask participants what they actually experienced. For example, ...
Julius Hamilton's user avatar
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Reducing pareidolia?

Going in the opposite direction and artificially increasing Pareidolia (the tendency for perception to impose a meaningful interpretation on a nebulous stimulus, usually visual, so that one sees an ...
bigbrainboy's user avatar
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3 answers
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What is the name of the tendency to portray oneself in the positive light?

I know it exists and it has a name... But my google-fu skills are lacking, due to a pretty niche concept that uses a lot of generic keywords. There is a fallacy / mental model / a tendency for people ...
Mars Robertson's user avatar
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Is the harm of uncommon drugs more feared than is justified?

I sometimes feel very cautious about the idea of taking a substance just because it is not culturally mainstream. It is much easier for people to say “We don’t know what the longterm effects are” ...
Julius Hamilton's user avatar
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What is the most ideal way to study the effect of a drug on a person over time?

What is the theoretically most optimal way of determining the longterm effects of a drug? Is it large scale population studies in which questionnaires determine frequency of use of a drug and ...
Julius Hamilton's user avatar
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Would you still be addicted to something if you lost your memory of being addicted to it? [duplicate]

If someone was addicted to something, it could be substances/gambling/sex etc... and then they lost their memory. It could be just losing the memory of the addiction or full blown global amnesia ...
Umayr Dawood's user avatar
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Any statistics on the likelihood of, consumption frequencies and dosages required for serotonin syndrome to occur with LSD?

This may be too obscure of a question to have sufficient, if any, statistics on it. If that's the case, any relevant information is appreciated. From what I've gathered, very high doses and/or very ...
A. Kvåle's user avatar
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The differences between sensory distortions and hallucinations

So, the way I've understood it, "sensory disturbances" can be categorized as follows: Any sensory experience that isn't real goes under "sensory disturbances" in this diagram. If ...
A. Kvåle's user avatar
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How to take advantage of the withdrawal symptoms of antidopaminergics?

So this may be a stupid question as I am not trained in neuroscience or psychology at all, but I had an idea about a somewhat counterintuitive approach to psychotropics and was wondering whether if it ...
pctree's user avatar
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Will smoking marijuana lightly during teens cause developmental damage to the brain?

If someone were to smoke marijuana lightly during his teens and stop abruptly in his adulthood. Would he suffer from Some type of damage to his short term memory/iq and if so can the damage be ...
Yaniv Arazi's user avatar
2 votes
2 answers
6k views

Is fasting an effective method to overcome substance addictions?

I recently watched a testimony of a man who reports the results of a 40-day water/juice fast (no food). The individual claims to have been addicted to drugs for 22 years, including marijuana, cocaine, ...
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1 vote
1 answer
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Can anticholinergics like benztropine be used to treat Catatonia?

I found an old paper describing a case study where a catatonic patient was successfully treated with benztropine (Cogentin). However, I can't find any modern guidelines that calls for this treatment (...
D.Tan's user avatar
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What recreational drugs have especially negative interactions with bipolar disorder?

I'm trying to find out which recreational drugs have the biggest negative interactions with BD (bipolar disorder types I and II) but haven't been able to find strong research. I especially ...
Jeremy Hadfield's user avatar
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Reducing smoking and mental health benefits

Recently I noticed improved mental health (better mood, better cognition? more energy) after reducing smoking.Is it backed up by research? I know stopping smoking is, but reducing? http://www....
george's user avatar
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1 vote
1 answer
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Smoking and cognitive abilities

How does smoking affect cognitive abilities? Could it have a positive impact on alertness (like coffee)? Could it reduce our ability to concentrate? Could it lead to less oxygen in the brain, and ...
Quora Feans's user avatar
2 votes
2 answers
184 views

Csikszentmihalyi on drugs and their effect

This is an excerpt from pp. 169-170 of a book named Flow: the psychology of optimal experience, written by Mihaly Csikszentmihalyi . It has become very difficult to understand the meaning of this <...
Sudhir Sharma's user avatar
3 votes
1 answer
232 views

Long term cocaine use and personality change - Scientific references?

I've experienced cocaine addicts first hand and noticed the development of egoistic personality traits such as selfishness or loss of empathy in cocaine addicts. Are there any scientific references ...
CuriousIndeed's user avatar
4 votes
1 answer
381 views

Are neural adaptation and drug tolerance to psychoactive drugs related?

Neural adaptation is "...a change over time in the responsiveness of the sensory system to a constant stimulus". The example given is placing your hand on the surface of a table. Eventually, you no ...
Alex S's user avatar
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2 answers
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Popular science books introducing therapeutic use of psychedelic drugs

I'm not a psychologist nor a psychiatrist, but I have the impression that research of therapeutic use of psychedelic drugs (MDMA, LSD, DMT, etc) is undergoing a revival and is very slowly being ...
Juliano B. Nequirito's user avatar
5 votes
2 answers
314 views

How addictive is Heroine?

I keep hearing that "*Heroine is so addictive the very first dose is enough to get you hooked on it*". Personally, I have a hard time believing any substance could do that to you. But I could believe ...
User1291's user avatar
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4 votes
4 answers
289 views

Why aren't any advancements being made in physically diagnosing Bipolar and other psychiatric disorders?

I was involved in a discussion where somebody had asked if others had thoughts of doing risky things during their manic episodes. Two people commented, including myself. I worried that only relying on ...
HeavenlyHarmony's user avatar
1 vote
0 answers
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What determines inebriated personality?

I've studied that alcohol impairs the functioning of the limbic system, slows functioning of the prefrontal cortex, which alters judgement and reason, and damages neurons leading to memory failure, ...
TheAutomaton's user avatar
4 votes
2 answers
548 views

Does a general impairment test exist, that specifically would be useful for the context of driving?

We know that alcohol negatively influences a driver's ability to drive. Governments typically combat this by making drunk driving illegal, and use the concentration of alcohol in breath or blood as ...
dwjohnston's user avatar
5 votes
2 answers
160 views

What exactly does paranoid mean in terms of psychoactive drugs?

When I went to my local marijuana dispensory, since recreational use of it is legal, they told me that when I first use it, I might get paranoid. When I read this word in context, I imagined somebody ...
HeavenlyHarmony's user avatar
1 vote
1 answer
247 views

Are many anticonvulsants just coincidentally also psychoactive?

Many of the antiseizure I'm aware of are described as having the potential for behavior altering side-effects. I am curious about this. Is there something about the chemistry of the brain that ...
Khae's user avatar
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9 votes
2 answers
247 views

Childhood IQ and pattern of drug use in adulthood

A study by White et al. (2012) using a large UK sample concludes that In this cohort, high childhood IQ was related to illegal drug use in adulthood. Note that this does not refer to habitual ...
the gods from engineering's user avatar
6 votes
1 answer
347 views

Is it dangerous to take an antipsychotic drug irregularly?

I've read the case of Witty Ticcy Ray: a 24 years old man with disabling Tourette’s syndrome. The first Dr. Sacks's treatment, with Haldol, provokes a strong change in Ray's behavior: from tics and ...
Fil's user avatar
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4 votes
1 answer
627 views

Does consumption of amino acid supplements improve human executive function and self-regulation in ADHD cases?

Based on my understanding, executive function primarily takes place in the frontal lobes. Inzlicht and Gutsell found that exhaustion in mental tasks shows itself in decreased activity in the anterior ...
Wuschelbeutel Kartoffelhuhn's user avatar
1 vote
1 answer
468 views

Yerkes-Dodson Law and Drugs

According to the Yerkes-Dodson Law, there is optimal point of arousal and performance. Suppose a person takes a stimulant such as Adderall. This would increase his arousal. However, it may increase ...
guest1234's user avatar
3 votes
1 answer
239 views

Why does an addict always remain one? [closed]

I'm asking this from a purely psychological and biological viewpoint, mainly why a drug addict is said to always remain one, even after sobering up.
Alex's user avatar
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1 answer
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Does the use of cannabis affect the ability to recall dreams?

Will cannabis be a negative factor in the ability to recall dreams from waking up. How do the cannabinoids affect you when in a dreaming state?
Billy Boyo's user avatar