Eysenck is a popular theorist who proposed a biological basis for Extraversion, Psychoticism, and Neuroticism. He didn't do a lot of empirical research but his theory has influenced researchers, see Chapman and Weiss.
I think the simple and obvious answer to this question is "Yes". That is, everyone at some point in their life is likely to make a 'big mistake'.
Regret is the likely emotion felt subsequent to making a 'big mistake' and is a well researched topic as per the references below.
There are countless situations in which an individual is likely to feel ...