**Short answer**  
Based on a dated and small study, early-blind individuals do not experience drug-induced hallucinations, while the late-blind can, but not necessarily do so.  

**Background**  
[Krill *et al*. (1963)][1] investigated the effects of LSD on totally blind people (i.e., no residual vision) and they report visual hallucinations in 13 out of 24 subjects. This study shortly reviews three other studies in this field (LSD and mescalin administered to blind people) and the consensus the authors reach is that blind folks do experience visual hallucinations.

However, as @JoeBathelt very rightfully notes, it is important to acknowledge the difference between **congenitally** blind and **late blind** people that lost vision later in life. Late-blind individuals often experience visual imagery, while congenitally blind do not and cannot. In the Krill *et al.* study linked, they included four congenitally blind subjects. They lost their vision at or before the age of two (which I would call early blind, but that's debatable). None of these 4 subjects experienced hallucinations. Given that half of their study group experienced hallucinations, one would expect two of these four to have experienced hallucinations. Although the congenitally (i.e., early-blind) group was small, it leads me to believe that prior visual experience at least early in life is a prerequisite for visual hallucinations to occur. However, not many studies have been published on the topic and I am most curious to see more answers to this most interesting question.   

<sub>**Reference**  
**-** [Krill *et al*., *Arch Ophthal* (1963); **6**: 180-5][1]</sub>


  [1]: http://www.lycaeum.org/research/researchpdfs/1094.pdf