Questions tagged [theoretical-neuroscience]

For questions about mathematical and computational neuroscience.

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Why is my memory composed of so many flashbulb memories? [closed]

I recently learned about flashbulb memories from Reddit and I seem to have a large amount of them in my memory. Yet they are just isolated bubbles. I don’t have a consistent hyperthemsia, just spurts. ...
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62 views

What comes first? Thought or electric activity?

Our thoughts are basically the result of the electro chemical activity which are happening in our neurons. The signals sent by different neurons to each other back and forth create a pattern which we ...
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Neuroscience & Epistemology - Feedback in Hermeneutic circle of Theory and Experiment

How good is neuroscience at closing this Hermeneutic circle in the Philosophy of science? I am referring to the interplay of theory and experiment. This is depicted in the following figure: ...
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Is short-term memory theoretically possible to with spiking neurons?

So I close my eyes, turn around, open them for just a blink and close again. I have observed a chair. I can't tell you how the chair looks like in detail, but I can more or less tell its shape and ...
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How does Functional Electrical Stimulation (FES) restore motor functions and non-motor functions in SCI patients

I am an engineer dealing with Brain-Computer Interface, and at the moment, in a clinical context. One area which I came across was rehabilitation for patients suffering from Spinal Cord Injuries or ...
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Surface area in the classic Hodgkin Huxley Model

How can I vary the membrane surface in the classic HH model? I have programmed such a model and now I ask myself how I can change the surface of the compartment, so which parameters I have to increase ...
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Relative Spread and fibre diameter of nerves

Verveen published in 1962 that the relative spread and diameter of nerve fibers have a negative linear log(relative spread) to log(diameter) relationship. Are there others besides this publication ...
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Deriving Fourier transform of auto correlation function from probability distribution

I am self studying a book "Neuronal Dynamics" https://neuronaldynamics.epfl.ch/online/index.html And I found this very challenging to derive this from p_0 https://neuronaldynamics.epfl.ch/...
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Single neuron dominates for all input patterns using STDP in simple LIF SNN

I have been reading latley on SNN and decided to try and implement myself some simple simulation. So I wrote a simple MATLAB simulation using simple LIF current based model and I try using STDP to ...
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Is it true that mirror neurons can make a man with an amputated arm feel sensation just by looking at someone else's arm, like Ramachandran said?

In this Ted Talk Ramachandran sais that mirror neurons can make a person with an amputated arm feel sensation, is it true? And if so, why doesn't the brain feel a sensation by looking at someone else'...
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125 views

Is pleasure synonymous to positive reinforcement?

I'm thinking about what pleasure is from the perspective of the integrated information theory of consciousness. As I understand it, according to the appraisal theory of emotions, the orientation on ...
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49 views

Can two neurons stimulate each other?

Is it possible that two neurons stimulate each other in an everlasting two neuron circuit?
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79 views

Is there any justification for viewing neurons as self-interested agents?

There are aspects of cognition that are vaguely reminiscent of markets within an economy. For example, there is specialization as well as integration within both brains and economies. One of the ...
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61 views

Theoretical Neuroscience: what tools are in your mathematical toolkit?

I believe that the following courses are a minimum math/engineering/(+cs) requirement for theoretical neuroscience research, specifically, Eliasmith's NEF/SPA approach. I wonder what other tools might ...
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Alternative hypotheses to Hebb's rule

I was reading on wikipedia that there are exceptions to the hebbian rule, and I was curious about the possibilities of other hypotheses of how learning occur in the brain. So I would like to know: ...
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What effect does the size of the soma have on firing characteristics?

For example, cells in layer 5 of the neocortex have a larger soma than do other layers. I'm wondering what the functional difference is between smaller and larger soma. On one hand, I can imagine that ...
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63 views

Equivalent Circuit of cell membrane potential

From chapter $7$ of Kandel et all's Principles of Neural Science:, Go to page 12, Box 7-2 (particular image attached below) The author claims that $$V_m = E_{Na} + I_{Na} / g_{Na}$$ on one side of ...
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29 views

In Integrate-and-fire models, why can we assume spike arrivals to be random?

I'm reading through some notes on integrate and fire models and it says that we assume that spike arrivals are random. Why exactly can we make this assumption? Is it because experiments haven't ...
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Minimum constant neuron firing rate

Please forgive what may be an elementary question for many of you. I am trying to understand the range of firing rates in an idealized neuron. I understand what governs the maximum firing rate of a ...
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Testing Multilayer Perceptron [closed]

The following script is from Trappenberg's Fundamentals of Computational Neuroscience and is used to test a perceptron's robustness against noise. However, how would one alter it to test the output ...
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51 views

Energy supply to brain

I wonder if the energy delivered to brain per unit time to maintain brain processes is limited and fairly constant? Is all provided energy fully used?
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Extra-classical receptive fields are surprising, but retinal ganglion receptive fields are not. Why?

Rao and Ballard (1999) start their paper by stating that extra-classical receptive fields, which exhibit the phenomenon of end-stopping are difficult to explain. They show that in an idealized ...
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Understanding the transition from integrated form to ODE form of neuron models

I'm trying to convert a fairly complicated neuron model from integrated form (a form of the spike response model) to ODE form for use in the BRIAN simulator. The BRIAN simulator requires neuron/...
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602 views

Predicting the individual effects of psychotropic drugs

https://www.ncbi.nlm.nih.gov/m/pubmed/23796468/ I have searched the national library of medicine but I could not find any papers about predicting both the therapeutic and adverse effects on the ...
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Have “Sapir-Whorf sensitivity” and “differential neuroplasticity” been considered so far?

I watched the movie "Arrival" today and came to define the concept of "Sapir-Whorf sensitivity" as the measure of to what extent is the way of thinking of somebody influenced by the languages they ...
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139 views

Does monism imply that computers can have consciousness?

According to The Basic Theory of the Mind, the mind is not a different entity from the brain, but an emergent property of the brain. Based on this assertion, can it be concluded that computers and ...
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129 views

Is there any Sleep limit for a human body?

Can we sleep throughout our whole life if we are supplied the necessary things like food,water etc.
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Methods to find patterns or correlations in MEA spike trains

I am looking for methods currently used to analyze micro-electrode arrays spike trains and figure out patterns, as repeated sequences of activation or spacial correlations. I know about ISI ...
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156 views

Biologically plausible models for causal inference in the human brain

Introduction: In ‘Is coding a relevant metaphor for the brain?’(2018) Romain Brette argues that the causal structure of neural codes (linear, atemporal) is incongruent with the causal structure of the ...
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68 views

Constraints on dataset size for AI-assisted connectome reconstruction

From an exchange with Dr. Seung, an expert on connectomics, I learned that one of his former PhD students Viren Jain is leading the Connectomic effort at Google using supervised learning methods. Now, ...
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331 views

ML/Neuroscience: TensorFlow vs PyTorch vs Keras for bulding NN models of the nervous system?

I would be very grateful to people with experience in using neural network models in neuroscience for advice! What approach would you recommend for building neural networks? I am choosing between ...
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193 views

Good neuroscience research blogs

In the field of AI research there are really good research blogs that regularly analyse methods and review papers. Examples that come to mind are: BAIR blog: The Berkeley AI Research blog Distill: an ...
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112 views

Understanding the 'Wiring Catastrophe'

Introduction: In 'Wiring optimization in the brain'(2000), Dmitri Chklovskii and Charles Stevens analyse the dependence of the complexity of cortical circuits on the number of synapses per neuron ...
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110 views

Modelling the Human Brain as a directed graph

A mathematician on the MathOverflow, Hans-Peter Stricker, recently(2016) considered the possibility that human brains may be modelled as directed graphs with neurons as nodes and synapses as edges. I ...
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210 views

What's the pathfinding algorithm the human brain uses?

I was trying to build a software simulation of people using different pathways in a city to get from point A to point B. I do know the Dijkstra's algorithm and the A* algorithm, but what they do is to ...
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157 views

What sources of randomness does the brain use for sampling?

As an applied mathematician, I have a growing interest in the mechanisms for uncertainty representation and computation in the human brain. In fact, I recently compiled a list of papers on this ...
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What is the state of the art on the wiring optimisation problem?

One of the earliest neuroscientists, Santiago Ramón y Cajal, postulated that brains are arranged to minimise wire length [1]. In [1] Dmitri Chklovskii and Charles Stevens formulate this problem as ...
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51 views

Homogeneous Poisson Process of spike train

In Theoretical Neuroscience by Dayan and Abbott page 25, the probability $P[t_1, t_2, ..., t_n]$ that a sequence of n spikes occurs with spike $i$ falling between times $t_i$ and $t_i+\Delta t$ ...
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Simulating Hudgkin Huxley neural network

I'm starting work on a computational neuroscience project where I want to create my own model of a spiking Hodgkin-Huxley neuron and connect many instances (about 400) of this model through synapses. ...
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Timeframe in which thoughts are concieved [closed]

Are thoughts concieved in realtime or are they preprocessed chains ready to be thought or both (depending on the prospective) or am I asking a too generalized question to have any sense ?
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Cerebellum question

Sorry if this sounds at all like pretentious armchair theorizing(it basically is), but I have a question which I can't really figure out how to search. So, given the resemblance of the cerebellum to ...
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126 views

Integrated Information Theory - If correct could humans create artificial consciousness?

First off please keep in mind I am self-learning and am learning about this for fun, I have no end goal. I'm trying to make predictions about what I am learning implies or means, so I can ask better ...
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42 views

Is there any evidence for or against the existence of neurons that encode surface slant in vision?

In the way orientation columns display selectivity for various edge orientations projected on the retina which is then repeated at various angles in a localised region of the cortex. I am wondering ...
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70 views

How to define “current” in artificial neural network?

How do neuroscientists define current/current densities in artificial neural networks? Assume I have some deep network and I would like to study its dynamic/evolution in time during the training ...
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86 views

What tasks is Spaun 2.0 able to perform?

According to "A Large-Scale Model of the Functioning Brain" by Eliasmith et al., Spaun 1.0 was able to perform 8 distinct cognitive tasks: Copy Drawing: Given a randomly chosen handwritten digit, ...
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27 views

MEG from simulated neurons

Given MEG is an approximation of neuronal spiking, are there any models that associate the spiking of simulated neurons to an MEG signal? Ideally, this would be a model with some amount of behaviour (...
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38 views

Name of association phenomenon

What is the name of the problem to explain how the neural activation for "red circle and a blue triangle" is different from "blue circle and red triangle"? Just activating the neurons for "red", "blue"...
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107 views

What extent is non linear dynamics and chaos helpful to study brain function?

Recently I've started reading dynamical systems in neuroscience by izhikevich and was fascinated by the subject. I would like to pursue PhD in computational neuroscience after my masters. Is it worth ...
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96 views

What are the neurological similarities between humans and primates?

I don't know exactly what primate specie is considered to be out ancestor. But the next question regards them. Assuming that in the beginning *we considered true the remnants of many trial & ...
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Does anybody know a source having multi-electrode (several channels) recorded data of multiple Neurons (I prefer real data not artificial)?

I mean recorded data of multiple Neurons with multi-electrode. I need this data as the input for my experiment.

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