Questions tagged [theoretical-neuroscience]
For questions about mathematical and computational neuroscience.
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What is the difference in amplitude and latency of IPSPs or EPSPs?
I'm building a Jansen & Rit whole brain model. In the original paper, it states:
A and B determine the maximum
amplitude of the excitatory and inhibitory PSP (EPSP
and IPSP), respectively, and a ...
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Improving System 1 and System 2 collaboration?
I'm an inquisitive novice with 60+ life years experience. My current top interest is the improvement of solutions created by organizations of teams solving complex problems cooperatively .
Is there ...
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Does Consciousness require a Structured Physical System?
I have been studying Giulio Tononi's Integrated Information Theory, and there he mentions 5 characteristics of human conscious experience (source: http://www.scholarpedia.org/article/...
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Non-salience memories? [duplicate]
It is said that memories that are significant are remembered much more clearly due to salience. Yet, let us imagine a man named Fred. Fred does not have hyperthymesia as he forgets things like ...
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Is there a complete overview and classification of all Probabilistic Neuronal Codes (PPC)?
I am trying to gather an explicit and complete overview of so-called Probabilistic Neuronal Codes (PPC). I have found various PPC models from literature, but have difficulties having them classified, ...
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Does the Nernst equilibrium in a neuron for a specific ion represent the potential voltage that would be needed to bring the net to 0?
I am learning about the Nernst equilibrium in a neuron (along with the Goldman equation), and while I understand certain concepts individually, I struggle to bring it all together. The Nernst ...
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Is it possible to completely describe a real object in terms of brain activity?
I've read that the way perception works in the brain, stimuli from the external world is converted into signals that travel through the brain until they reach regions of the brain that can "...
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Network Architecture Diagram
I am trying to teach myself some computational neuroscience and am reading through the following textbook: https://www.oxcns.org/b6_text.html.
I'm finding this diagram confusing in particular c). My ...
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Are there open data for long-term potentiation/depression experiments?
The following is Figure 8.2 from Dayan & Abbott (2001), p. 292:
It describes the phenomenon of long-term potentiation/depression (LTP/LTD): Change in synaptic strength (y-axis) is inversely ...
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How long does it take (on average/etimated) a neuron to fire?
I'm not from a neuroscience field but I'm curious about this. I would like to know how long does it take for the membrane potential of a neuron to go from its resting value to its threshold value ( ...
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Why do we understand so little about the brain? [closed]
Most of the things our brain does we have no clue how it does it. Thought, Memory storage and recall, dreaming, spatial awareness, timekeeping, emotions, pain and the big ONE- qualia. We have no clue ...
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How does brain makes descisons? [closed]
I have recently started studying about brain network analysis, Does brain makes decisions based on neuron connections? ex: If say 10 neurons were there, if I see pen to recognize that as pen does the ...
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Why do some people have better memories than others?
Some people have great memories. Some people have horrible memories. There are even people with hyperthymesia who remember everything. I was told that anybody can have a good memory if they practice ...
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where is the second electrode in case of electrostimulation
With electrostimulation or functional electrostimulation, a response from the neuron is generated by electrical impulses.
But I always read, for example, that a stimulating electrode is above position ...
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Do induced brain wave patterns give the same cognitive and perceptual consequences as those that arise naturally? [duplicate]
What I mean to ask by this particular question is that, are the effects resulting from neural interactions in the brain that cause the emergence of certain behaviours, with the neural frequencies in ...
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What are the values of the absolute intracellular and absolute extracellular potentials in a neuron?
Most texts on neurons give the value of the membrane potential and do not state the absolute values of the intracellular and extracellular potentials in a neuron. I understand that this is because the ...
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Why is it only positive charge that gets injected into a neuron when we inject a current into it?
Learning about the basics of theoretical neuroscience from the youtube lectures from Michale Fee's introduction to neural computation course.
We're considering a very simplified model of a neuron, ...
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What comes first? Thought or electric activity?
Our thoughts are basically the result of the electro chemical activity which are happening in our neurons. The signals sent by different neurons to each other back and forth create a pattern which we ...
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Is short-term memory theoretically possible to with spiking neurons?
So I close my eyes, turn around, open them for just a blink and close again. I have observed a chair. I can't tell you how the chair looks like in detail, but I can more or less tell its shape and ...
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Deriving Fourier transform of auto correlation function from probability distribution
I am self studying a book "Neuronal Dynamics" https://neuronaldynamics.epfl.ch/online/index.html
And I found this very challenging to derive this from p_0
https://neuronaldynamics.epfl.ch/...
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Single neuron dominates for all input patterns using STDP in simple LIF SNN
I have been reading latley on SNN and decided to try and implement myself some simple simulation.
So I wrote a simple MATLAB simulation using simple LIF current based model and I try using STDP to ...
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Is it true that mirror neurons can make a man with an amputated arm feel sensation just by looking at someone else's arm, like Ramachandran said?
In this Ted Talk Ramachandran sais that mirror neurons can make a person with an amputated arm feel sensation, is it true? And if so, why doesn't the brain feel a sensation by looking at someone else'...
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Is pleasure synonymous to positive reinforcement?
I'm thinking about what pleasure is from the perspective of the integrated information theory of consciousness. As I understand it, according to the appraisal theory of emotions, the orientation on ...
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Can two neurons stimulate each other?
Is it possible that two neurons stimulate each other in an everlasting two neuron circuit?
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Is there any justification for viewing neurons as self-interested agents?
There are aspects of cognition that are vaguely reminiscent of markets within an economy. For example, there is specialization as well as integration within both brains and economies. One of the ...
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Theoretical Neuroscience: what tools are in your mathematical toolkit?
I believe that the following courses are a minimum math/engineering/(+cs) requirement for theoretical neuroscience research, specifically, Eliasmith's NEF/SPA approach. I wonder what other tools might ...
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Alternative hypotheses to Hebb's rule
I was reading on wikipedia that there are exceptions to the hebbian rule, and I was curious about the possibilities of other hypotheses of how learning occur in the brain. So I would like to know:
...
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What effect does the size of the soma have on firing characteristics?
For example, cells in layer 5 of the neocortex have a larger soma than do other layers. I'm wondering what the functional difference is between smaller and larger soma. On one hand, I can imagine that ...
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Equivalent Circuit of cell membrane potential
From chapter $7$ of Kandel et all's Principles of Neural Science:, Go to page 12, Box 7-2 (particular image attached below)
The author claims that $$V_m = E_{Na} + I_{Na} / g_{Na}$$ on one side of ...
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In Integrate-and-fire models, why can we assume spike arrivals to be random?
I'm reading through some notes on integrate and fire models and it says that we assume that spike arrivals are random.
Why exactly can we make this assumption?
Is it because experiments haven't ...
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Minimum constant neuron firing rate
Please forgive what may be an elementary question for many of you.
I am trying to understand the range of firing rates in an idealized neuron.
I understand what governs the maximum firing rate of a ...
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Testing Multilayer Perceptron [closed]
The following script is from Trappenberg's Fundamentals of Computational Neuroscience and is used to test a perceptron's robustness against noise.
However, how would one alter it to test the output ...
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Energy supply to brain
I wonder if the energy delivered to brain per unit time to maintain brain processes is limited and fairly constant? Is all provided energy fully used?
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Extra-classical receptive fields are surprising, but retinal ganglion receptive fields are not. Why?
Rao and Ballard (1999) start their paper by stating that extra-classical receptive fields, which exhibit the phenomenon of end-stopping are difficult to explain. They show that in an idealized ...
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Understanding the transition from integrated form to ODE form of neuron models
I'm trying to convert a fairly complicated neuron model from integrated form (a form of the spike response model) to ODE form for use in the BRIAN simulator.
The BRIAN simulator requires neuron/...
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Predicting the individual effects of psychotropic drugs
https://www.ncbi.nlm.nih.gov/m/pubmed/23796468/
I have searched the national library of medicine but I could not find any papers about predicting both the therapeutic and adverse effects on the ...
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Have "Sapir-Whorf sensitivity" and "differential neuroplasticity" been considered so far?
I watched the movie "Arrival" today and came to define the concept of "Sapir-Whorf sensitivity" as the measure of to what extent is the way of thinking of somebody influenced by the languages they ...
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Does monism imply that computers can have consciousness?
According to The Basic Theory of the Mind, the mind is not a different entity from the brain, but an emergent property of the brain. Based on this assertion, can it be concluded that computers and ...
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608
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Is there any Sleep limit for a human body?
Can we sleep throughout our whole life if we are supplied the necessary things like food,water etc.
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Methods to find patterns or correlations in MEA spike trains
I am looking for methods currently used to analyze micro-electrode arrays spike trains and figure out patterns, as repeated sequences of activation or spacial correlations.
I know about ISI ...
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Biologically plausible models for causal inference in the human brain
Introduction:
In ‘Is coding a relevant metaphor for the brain?’(2018) Romain Brette argues that the causal structure of neural codes (linear, atemporal) is incongruent with the causal structure of
the ...
user3503
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Constraints on dataset size for AI-assisted connectome reconstruction
From an exchange with Dr. Seung, an expert on connectomics, I learned that one of his former PhD students Viren Jain is leading the Connectomic effort at Google using supervised learning methods. Now, ...
user3503
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ML/Neuroscience: TensorFlow vs PyTorch vs Keras for bulding NN models of the nervous system?
I would be very grateful to people with experience in using neural network models in neuroscience for advice!
What approach would you recommend for building neural networks?
I am choosing between ...
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Good neuroscience research blogs
In the field of AI research there are really good research blogs that regularly analyse methods and review papers. Examples that come to mind are:
BAIR blog: The Berkeley AI Research blog
Distill: an ...
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Understanding the 'Wiring Catastrophe'
Introduction:
In 'Wiring optimization in the brain'(2000), Dmitri Chklovskii and Charles Stevens
analyse the dependence of the complexity of cortical circuits on the number of synapses per neuron ...
user3503
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Modelling the Human Brain as a directed graph
A mathematician on the MathOverflow, Hans-Peter Stricker, recently(2016) considered the possibility that human brains may be modelled as directed graphs with neurons as nodes and synapses as edges. I ...
user3503
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What's the pathfinding algorithm the human brain uses?
I was trying to build a software simulation of people using different pathways in a city to get from point A to point B. I do know the Dijkstra's algorithm and the A* algorithm, but what they do is to ...
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What sources of randomness does the brain use for sampling?
As an applied mathematician, I have a growing interest in the mechanisms for uncertainty representation and computation in the human brain. In fact, I recently compiled a list of papers on this ...
user3503
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What is the state of the art on the wiring optimisation problem?
One of the earliest neuroscientists, Santiago Ramón y Cajal, postulated that brains are arranged to minimise wire length [1]. In [1] Dmitri Chklovskii and Charles Stevens formulate this problem as ...
user3503
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Homogeneous Poisson Process of spike train
In Theoretical Neuroscience by Dayan and Abbott page 25,
the probability $P[t_1, t_2, ..., t_n]$ that a sequence of n spikes occurs with spike $i$ falling between times $t_i$ and $t_i+\Delta t$ ...
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