Questions tagged [theoretical-neuroscience]

For questions about mathematical and computational neuroscience.

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Theoretical Neuroscience: what tools are in your mathematical toolkit?

I believe that the following courses are a minimum math/engineering/(+cs) requirement for theoretical neuroscience research, specifically, Eliasmith's NEF/SPA approach. I wonder what other tools might ...
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Alternative hypotheses to Hebb's rule

I was reading on wikipedia that there are exceptions to the hebbian rule, and I was curious about the possibilities of other hypotheses of how learning occur in the brain. So I would like to know: ...
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What effect does the size of the soma have on firing characteristics?

For example, cells in layer 5 of the neocortex have a larger soma than do other layers. I'm wondering what the functional difference is between smaller and larger soma. On one hand, I can imagine that ...
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1answer
32 views

Equivalent Circuit of cell membrane potential

From chapter $7$ of Kandel et all's Principles of Neural Science:, Go to page 12, Box 7-2 (particular image attached below) The author claims that $$V_m = E_{Na} + I_{Na} / g_{Na}$$ on one side of ...
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26 views

In Integrate-and-fire models, why can we assume spike arrivals to be random?

I'm reading through some notes on integrate and fire models and it says that we assume that spike arrivals are random. Why exactly can we make this assumption? Is it because experiments haven't ...
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Surgical implications of a fallacy in infering histology and morphology through a 1.5 Tesla MRI of a brainstem tumor

What would the surgical implications of a fallacy in infering histology and morphology of a brainstem tumour be? I am interested mainly in the sequelae in the sensory, motor and cognitive functions. ...
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23 views

Minimum constant neuron firing rate

Please forgive what may be an elementary question for many of you. I am trying to understand the range of firing rates in an idealized neuron. I understand what governs the maximum firing rate of a ...
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25 views

Testing Multilayer Perceptron [closed]

The following script is from Trappenberg's Fundamentals of Computational Neuroscience and is used to test a perceptron's robustness against noise. However, how would one alter it to test the output ...
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1answer
49 views

Energy supply to brain

I wonder if the energy delivered to brain per unit time to maintain brain processes is limited and fairly constant? Is all provided energy fully used?
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1answer
40 views

Extra-classical receptive fields are surprising, but retinal ganglion receptive fields are not. Why?

Rao and Ballard (1999) start their paper by stating that extra-classical receptive fields, which exhibit the phenomenon of end-stopping are difficult to explain. They show that in an idealized ...
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37 views

Understanding the transition from integrated form to ODE form of neuron models

I'm trying to convert a fairly complicated neuron model from integrated form (a form of the spike response model) to ODE form for use in the BRIAN simulator. The BRIAN simulator requires neuron/...
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3answers
589 views

Predicting the individual effects of psychotropic drugs

https://www.ncbi.nlm.nih.gov/m/pubmed/23796468/ I have searched the national library of medicine but I could not find any papers about predicting both the therapeutic and adverse effects on the ...
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Have “Sapir-Whorf sensitivity” and “differential neuroplasticity” been considered so far?

I watched the movie "Arrival" today and came to define the concept of "Sapir-Whorf sensitivity" as the measure of to what extent is the way of thinking of somebody influenced by the languages they ...
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1answer
115 views

Does monism imply that computers can have consciousness?

According to The Basic Theory of the Mind, the mind is not a different entity from the brain, but an emergent property of the brain. Based on this assertion, can it be concluded that computers and ...
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37 views

How does a brain learn strategies?

Imagine the simple task of finding words in a wordsearch. Initially the default strategy might be just to let your eyes wander around to see if you spot any words. Strategy 2 might be to search for ...
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1answer
79 views

Is there any Sleep limit for a human body?

Can we sleep throughout our whole life if we are supplied the necessary things like food,water etc.
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35 views

Methods to find patterns or correlations in MEA spike trains

I am looking for methods currently used to analyze micro-electrode arrays spike trains and figure out patterns, as repeated sequences of activation or spacial correlations. I know about ISI ...
2
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1answer
135 views

Biologically plausible models for causal inference in the human brain

Introduction: In ‘Is coding a relevant metaphor for the brain?’(2018) Romain Brette argues that the causal structure of neural codes (linear, atemporal) is incongruent with the causal structure of the ...
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1answer
66 views

Constraints on dataset size for AI-assisted connectome reconstruction

From an exchange with Dr. Seung, an expert on connectomics, I learned that one of his former PhD students Viren Jain is leading the Connectomic effort at Google using supervised learning methods. Now, ...
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2answers
251 views

ML/Neuroscience: TensorFlow vs PyTorch vs Keras for bulding NN models of the nervous system?

I would be very grateful to people with experience in using neural network models in neuroscience for advice! What approach would you recommend for building neural networks? I am choosing between ...
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2answers
174 views

Good neuroscience research blogs

In the field of AI research there are really good research blogs that regularly analyse methods and review papers. Examples that come to mind are: BAIR blog: The Berkeley AI Research blog Distill: an ...
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1answer
104 views

Understanding the 'Wiring Catastrophe'

Introduction: In 'Wiring optimization in the brain'(2000), Dmitri Chklovskii and Charles Stevens analyse the dependence of the complexity of cortical circuits on the number of synapses per neuron ...
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1answer
89 views

Modelling the Human Brain as a directed graph

A mathematician on the MathOverflow, Hans-Peter Stricker, recently(2016) considered the possibility that human brains may be modelled as directed graphs with neurons as nodes and synapses as edges. I ...
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126 views

What's the pathfinding algorithm the human brain uses?

I was trying to build a software simulation of people using different pathways in a city to get from point A to point B. I do know the Dijkstra's algorithm and the A* algorithm, but what they do is to ...
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136 views

What sources of randomness does the brain use for sampling?

As an applied mathematician, I have a growing interest in the mechanisms for uncertainty representation and computation in the human brain. In fact, I recently compiled a list of papers on this ...
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64 views

What is the state of the art on the wiring optimisation problem?

One of the earliest neuroscientists, Santiago Ramón y Cajal, postulated that brains are arranged to minimise wire length [1]. In [1] Dmitri Chklovskii and Charles Stevens formulate this problem as ...
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1answer
46 views

Homogeneous Poisson Process of spike train

In Theoretical Neuroscience by Dayan and Abbott page 25, the probability $P[t_1, t_2, ..., t_n]$ that a sequence of n spikes occurs with spike $i$ falling between times $t_i$ and $t_i+\Delta t$ ...
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2answers
65 views

Simulating Hudgkin Huxley neural network

I'm starting work on a computational neuroscience project where I want to create my own model of a spiking Hodgkin-Huxley neuron and connect many instances (about 400) of this model through synapses. ...
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31 views

Timeframe in which thoughts are concieved [closed]

Are thoughts concieved in realtime or are they preprocessed chains ready to be thought or both (depending on the prospective) or am I asking a too generalized question to have any sense ?
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81 views

Cerebellum question

Sorry if this sounds at all like pretentious armchair theorizing(it basically is), but I have a question which I can't really figure out how to search. So, given the resemblance of the cerebellum to ...
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1answer
118 views

Integrated Information Theory - If correct could humans create artificial consciousness?

First off please keep in mind I am self-learning and am learning about this for fun, I have no end goal. I'm trying to make predictions about what I am learning implies or means, so I can ask better ...
2
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1answer
42 views

Is there any evidence for or against the existence of neurons that encode surface slant in vision?

In the way orientation columns display selectivity for various edge orientations projected on the retina which is then repeated at various angles in a localised region of the cortex. I am wondering ...
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1answer
69 views

How to define “current” in artificial neural network?

How do neuroscientists define current/current densities in artificial neural networks? Assume I have some deep network and I would like to study its dynamic/evolution in time during the training ...
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1answer
76 views

What tasks is Spaun 2.0 able to perform?

According to "A Large-Scale Model of the Functioning Brain" by Eliasmith et al., Spaun 1.0 was able to perform 8 distinct cognitive tasks: Copy Drawing: Given a randomly chosen handwritten digit, ...
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1answer
25 views

MEG from simulated neurons

Given MEG is an approximation of neuronal spiking, are there any models that associate the spiking of simulated neurons to an MEG signal? Ideally, this would be a model with some amount of behaviour (...
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1answer
38 views

Name of association phenomenon

What is the name of the problem to explain how the neural activation for "red circle and a blue triangle" is different from "blue circle and red triangle"? Just activating the neurons for "red", "blue"...
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1answer
101 views

What extent is non linear dynamics and chaos helpful to study brain function?

Recently I've started reading dynamical systems in neuroscience by izhikevich and was fascinated by the subject. I would like to pursue PhD in computational neuroscience after my masters. Is it worth ...
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1answer
91 views

What are the neurological similarities between humans and primates?

I don't know exactly what primate specie is considered to be out ancestor. But the next question regards them. Assuming that in the beginning *we considered true the remnants of many trial & ...
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1answer
28 views

Does anybody know a source having multi-electrode (several channels) recorded data of multiple Neurons (I prefer real data not artificial)?

I mean recorded data of multiple Neurons with multi-electrode. I need this data as the input for my experiment.
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212 views

Brain and General Sections

Whereabouts in the brain gets triggered/switched on when an addictive substance is ingested/taken. I'm doing an addiction study with a couple of colleagues and would like some help with it.
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1answer
49 views

What are the top contributions from neuroscience to AI and viceversa? How much progress has been made from the interaction between these two fields?

What are the top contributions from neuroscience to artificial intelligence and viceversa? How much progress has been made from the interaction between these two fields? Is there a formal research ...
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1answer
185 views

Does neurodynamics have any relation to psychodynamics?

From Neural oscillation - Wikipedia: Neural oscillations are commonly studied from a mathematical framework and belong to the field of "neurodynamics", an area of research in the cognitive sciences ...
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1answer
99 views

Why is the hopfield network a model of associative memory?

I'm struggling to understand the meaning of the term associative memory in the context of Hopfield networks. I'm not sure if associative learning is the same thing or a different thing. In associative ...
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2answers
170 views

Are thoughts transferred along with a brain during a brain transplantation?

If I'm transplanted with, e.g., Stephen Hawking's brain, would I start to think like him, or would I remain to think like me? On which, "thinking" ability depends , is it the physical structure of ...
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50 views

Is the phenomenom of “subjective consciousness” or “qualia” formally captured by any state-of-the-art Theoretical Model in Neuroscience?

Is the phenomenon of "subjective consciousness" or "qualia" formally captured or defined by any state-of-the-art Theoretical Model in Neuroscience? If so, can you share a brief summary of such ...
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1answer
28 views

Are cycles possible in circuits of neurons? [duplicate]

If we consider neurons nodes and connections between them edges, are cycles (from graph theory) are possible in the brain? To put it another way, would the signal generated from ...
3
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1answer
46 views

How long can neuron adaptation last?

One way to model a neuron which adapts to input current is an Adaptive LIF [1]. In this model, the input current is subtracted by $n$, which changes with $dn=\frac{-n}{\tau_n}dt$ [2] and $n$ is ...
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43 views

Why we construct and estimate human brain models? [closed]

Based on clinical data collected using different brain imaging, researchers build a mathematical model of the activity of the human brain like the hemodynamic model (Friston, 2000) that describes the ...
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1answer
57 views

In TD learning, is the weight function used as a linear filter?

In the Temporal difference learning algorithm (TD-learning), an agent seeks to predict the total value of future rewards that will be received during the current trial. The agent updates the ...
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1answer
71 views

Difference between brain and electronic device signals

As I understand it, a brain communicates through sending signals via ions and chemical reactions resulting in concentrations of ions, a computer sends signals by electrons. I'm really trying to do 3 ...

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