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Questions tagged [psychopharmacology]

For questions about the scientific study of the effects of pharmaceutical and general drugs on perception, behavior, mood and cognition.

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How should medication for the treatment of ADHD symptoms be calibrated?

My understanding is that the treatment of ADHD symptoms with stimulant medication is a balancing act between alleviating ADHD symptoms, and not producing unwanted side effects like insomnia or anxiety....
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1answer
98 views

Are neural adaptation and drug tolerance to psychoactive drugs related?

Neural adaptation is "...a change over time in the responsiveness of the sensory system to a constant stimulus". The example given is placing your hand on the surface of a table. Eventually, you no ...
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1answer
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What genetic polymorphisms are linked to aggression or violence?

Anecdotally, there are reports of varenicline causing agression, but larger studies tended towards the finding of no effect over controls. This got me into thinking about possible genetic ...
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0answers
100 views

Evidence of cannabis exposure causing schizophrenia?

I've heard that cannabis exposure during teenage years increases the probability of developing schizophrenia-like symptoms later in life. What evidence is there that this is causal and not ...
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0answers
123 views

Influence of antidepressant drugs upon personality

How do antidepressant drugs influence someone's personality? Do they induce a major change in an individual's personality, or do they just negate the influence of depression? Basically, is the ...
3
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0answers
75 views

Interaction between caffeine intake and biorhythm on alertness

Throughout the day, people's wakefulness and attentiveness varies, as modulated by one's circadian biorhythm. Whereas in the morning people are less awake, just before noon and around 15:00 people ...
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0answers
137 views

What happens inside our body, when we experience betrayal and infidelity?

I guess many of us have experienced it. The moment that you understand that "the person you love, in whom you've trusted, is now with someone else, enjoying every moment with him/her". It's so ...
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0answers
46 views

Study purportedly proving psychedelics induce a “heightened state of consciousness”

The Guardian headlines on 28 Nov 2017: "Psychedelic drugs induce 'heightened state of consciousness', brain scans show". Healthy volunteers who received LSD, ketamine or psilocybin, a compound ...
2
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0answers
48 views

Caffeine any-dose tolerance study

Lifehacker says: A 1995 study suggests that humans become tolerant to their daily dose of caffeine—whether a single soda or a serious espresso habit—somewhere between a week and 12 days. They don'...
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0answers
104 views

Can tapering reduce the risk of sedative kindling and brain damage?

So we know that repeated withdrawal from GABAeric substances like alcohol and benzodiazepines will cause kindling and worsen future withdrawal symptoms. Also, it appears that withdrawal from alcohol ...
2
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0answers
158 views

Are many anticonvulsants just coincidentally also psychoactive?

Many of the antiseizure I'm aware of are described as having the potential for behavior altering side-effects. I am curious about this. Is there something about the chemistry of the brain that ...
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0answers
12 views

Is there any empirical support to “chemical imbalance theory” for mental illness?

Has it been proved by measurement of chemicals in the brain that psychiatric disorders have either their origin or continuance due to chemical imbalance in the brain? I saw the documentary Diagnostic &...
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0answers
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Why does venlafaxine have lower incidence of sexual dysfunctions at higher doses?

Venlafaxine at low dosages strongly inhibits serotonin, at moderate dosages also norepinephrine and only high dosages it also inhibits dopamine. The ratio is the following. serotonin : ...
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Mechanism of ketamine in treatment of depression and anxiety?

What are the mechanisms by which ketamine reduces the symptoms of depression and anxiety?
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Are there ways to accelerate the recovery from depression via novel pharmacological antidepressants?

Are there any scientists making substantial progress in the development of far more effective antidepressants? Are there any groups of people interested in developing antidepressants based on genetic ...