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Questions tagged [electrophysiology]

For questions about the study and measurement of the electrical activity of neurons

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99 views

Can an EEG be re-sampled to fix a poor voltage resolution? [migrated]

I’ve made quite a bad mistake in ca. 14 EEG recordings – I recorded at 10uV resolution @ 5000 Hz instead of 0.1 uV @ 500 Hz. I’m conducting an ERP experiment, and the signals of interest are on the ...
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1answer
50 views

Is there a region of the brain that mediates pain in a manner reminiscent of the mesolimbic pathway?

The mesolimbic dopamine pathway is a common neural pathway upon which rewards converge AKA the pleasure pathway. So I am trying to find a comparable pathway in the brain for pain -- is there such a ...
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1answer
23 views

Reference signal when measuring EEG

When performing EEG, a number of electrodes are placed on the scalp to measure the electric potential difference between those locations and a reference. In the unipolar configuration, the reference ...
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2answers
79 views

Parallel arrangement of capacitor and resistor in leaky integrate-and-fire model

I have read from several sources that in the leaky integrate-and-fire model of a single neuron resistor (leakage) and capacitor (membrane potential) are arranged in parallel. Look at the following RC ...
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1answer
166 views

What does “diffuse slowing” mean in the context of EEG and Alzheimer's?

Horvath et al. (2018) mention that: The disappearance of posterior dominant alpha rhythm and the diffuse slowing in AD (alzheimer disease) are easily detectable EEG signs for the experienced ...
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30 views

Inducing error-related negativity

Which tasks induce the strongest error-related negativity? I'm trying to build a classifier that measures EEG signals to detect when a subject observes an error being committed by another subject. It ...
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21 views

Somatosensory evoked potentials

I am wondering what the best EEG recording montage is to use for recording of electrically evoked somatosensory evoked potentials after median nerve stimulation?
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53 views

Statistic analysis on EEG data - how to deal with it properly?

Let's assume that I have a datasheet looking like that: ...
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1answer
125 views

Can I read what the person thinking through electrodes or something similar?

First of all I'm not a medical student so I may miss some points here. I know that EOG (electro-oculography) works on the corneo-retinal dipole. The cornea (front of eye) is slightly positively ...
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1answer
190 views

Can a bipolar EEG signal be converted to a monopolar (unipolar) one?

I have bipolar EEG signal of Fpz-Cz of EEG sleep data which I have downloaded from physionet. I would like to have Fpz signal for my sleep study. Is there any way I could convert a bipolar EEG signal ...
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33 views

Splitting EEG signal by marker using BrainVisionAnalyser

I have recorded a long EEG experiment with BrainVision equipment and I want to split it into smaller chunks based on marker numbers. For example, I want to have the chunk of recording between markers ...
4
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1answer
49 views

Simultaneous extracellular recording from different distant sites (in rodents)

I wonder whether it is technically possible today to have simultaneous extracellular recording in awake rodents (e.g., mice) from different non-proximate sites (e.g., V1 and frontal cortex). I mean to ...
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1answer
504 views

Can brain zaps be demonstrated by EEG?

Brain zaps are explained as an electrical buzz in the head and the symptoms occur while withdrawing slowly from an SSRI antidepressant medication. Is it possible to detect brain zaps by placing EEG ...
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2answers
93 views

Does the peripheral nervous system processes information like central neurons do?

Neural coding deals with the problem on how neurons or a network of neurons processes a stimulus and creates a response in form of electrical action potentials. Information then might be encoded in ...
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1answer
81 views

Latency between actual neurons firing and muscles response in open and close fist experiment

I'm trying to analyze the electrocorticograms (ECoG) of opening and closing the fist. I have the data of a glove to capture when the hand moves. I'm struggling with finding the best epoch or segment ...
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1answer
915 views

Where should I place a reference electrode?

This site gives basics of how to place electrodes for action potential recording. What I understand is that in order to get better signal, the reference electrode must be placed where there is minimum ...
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31 views

How close an electrode should be to the target neural tissue? [closed]

Intracortical electrodes are used to record neural signals. How close an electrode should be to the target neural tissue to obtain sufficiently clean / usable or hi-fidelity signal?
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18 views

Human trials for stentrode neural recordings

Neural recording via a stentrode seems to be next big thing in neuroscience. It can be used to treat disabilities, brain disorders and enable brain to brain communications. Are human trials being done ...
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1answer
36 views

What is the voltage that an intracortical electrode is expected to receive?

When a neuron fires, an action potential of about 100 mV is generated. An electrode measuring brain activity will record several hundreds neurons at a time. How much voltage an electrode directly in ...
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1answer
325 views

What is the meaning of the peak polarity in EEG data?

I wish to define neuronal activities by analyzing the peaks of each channel in EEG signals. Some papers use the negative peaks as a measure of neuronal activity and others deploy the positive peaks. ...
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1answer
104 views

How do you form a rationale to justify choice of time windows in ERP analysis?

Event-related potentials (ERPs) can reflect the electrophysiological phenomena behind perception & attention. Often, certain time windows are applied for the analysis of ERP peaks (components). I ...
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1answer
236 views

At what impedances should one gold plate 12.5-µm diameter nichrome wire tetrodes for targeting different brain areas?

Extracellular electrophysiological recordings of rodent brains using tetrodes requires plating them with gold solution in order to achieve appropriate impedances. How does the ideal plating ...
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0answers
120 views

Is there a reasonably easy way to get emotions from EEG?

I am building a project to visualise brain data from EEG, specifically emotions. I have found a significant numbers of papers that describe methods that include pre-processing, feature extraction and ...
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2answers
110 views

Why is Potassium(K) important to neurology & the brain?

When researching the pharmacological mechanisms of action and interactions that various psychotropic drugs, poisons, neurotoxins, etc. have on the brain: I frequently see off-hand references to the ...
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1answer
282 views

What is the role of (why )universal gas constant in Nernst equation?

The Nernst equation is an equation that relates the the total voltage, i.e. the electromotive force, of the full cell at any point in time to the standard electrode potential, temperature, activity, ...
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1answer
72 views

Membrane resistance of a neuron

I am about to simulate a neuron activity with the "Leaky Integrate and Fire" neuron model. But for that I need the membrane resistance. I was really looking a lot online, but I just cant find a value. ...
3
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1answer
107 views

How do neurons limit their input current?

I know that many neurons have an input current-spiking frequency (I-F) relationships, e.g. as seen here. However, all the I-F curves I've encountered show the input current in a fairly small range (...
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8k views

Are brain waves electromagnetic waves?

Depending upon its activity, the brain emits waves, which represent the summation of individual neurons firing. Are these waves electromagnetic waves?
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123 views

Silent speech recognition method or system with highest accuracy?

Is there any other silent speech recognition method (EEG/ECoG/Intracortical etc), with accuracy as good as the Audeo device developed by Michael Callahan and team - see the demo here, which is based ...
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1answer
1k views

Is there a way to make a DIY EEG?

I have MATLAB. I would like to try out a small EEG project because my field of interest is in neuroscience, however I'm still doing my undergrad.
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1answer
1k views

Voltage sensitive dyes technique: 2-photons microscopy vs confocal microscopy

I just discovered voltage sensitive dyes technique and I was wondering what would be the advantage to use 2-photons microscopy compared to confocal microscopy? They are both fluorescent techniques ...
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1answer
48 views

Voltage sensitive dyes technique: What is the underlying measure?

I just discovered voltage sensitive dyes technique: I have seen that figures are labelled with dF/F0, what does it stands for?
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1answer
186 views

How do I obtain recordings of the P300 wave of the event-related potential in the EEG?

I am trying to understand how to analyze the ERP (Event-Related Potentials) from EEG recordings and in particular the P300 wave. I have come up with a few questions which I hope you might be able to ...
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1answer
6k views

What is input resistance and how to interpret its values?

For example, this site gives a distribution of values of the input resistance of various cells. The values are in MOhms. The definition says that "input resistance measured at steady-state voltage ...
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2answers
111 views

Understanding neuronal firing in the context of Spike Timing Dependent Plasticity

When discussing Spike Timing Dependent Plasticity in neurons, when we say that a neuron fires do we mean it fires only one spike? Or do we still say "the neuron has fired" when a train of n spikes was ...
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2answers
25k views

What is the role of Chloride (Cl- ions) in membrane potential?

This Membrane Potential article mentions only that Cl- ion is used to model inhibitory GABA synapses. Does it have another role besides hyper-polarizing the cell due to inhibitory neurotransmitter ...
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1answer
712 views

Applications and Limitations of EEG Electrode Pooling - Averaging across time series

Is there any literature that has addressed electrode pooling? In particular, are there any standards concerning what pools (e.g. frontal, central, posterior vs. electrode pairs) could be used or any ...
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1answer
89 views

Is the weight of neural inputs in the human brain as central as it is for neurons in an artifical neural network?

As an example of an artificial neural net (ANN), a neural processing unit (NPU) is able to encode previous (learned) information by storing a weighted resistance for each input. Since ANN's are ...
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2answers
619 views

Grid cells : Between what is the correlation of autocorrelogram measured?

In their seminal paper Hafting, Torkel, et al. "Microstructure of a spatial map in the entorhinal cortex." Nature 436.7052 (2005): 801-806.‏ the Mosers have discovered the grid cells. To show the ...
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1answer
64 views

Is it possible to imitate two way communication between a brain and a limb?

Human muscles are controlled by action potentials that travel along the nerves. Below is an image of a train of action potentials that are decoded by the brain into a sensation or interpreted by a ...
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1answer
143 views

How to analyze auditory steady state responses?

How does one usually go about analyzing the auditory steady state response (ASSR)? I have data where speech was amplitude modulated to a 40 Hz sine tone. There's 3.5 minutes of data; should I just ...