From what I understand, only the oligodendrocytes are affected in multiple sclerosis, and they are attacked by T cells which cross the blood-brain barrier. This leads me to two questions:

  1. How is the blood-brain barrier affected in MS that allows T lymphocytes to cross the barrier?
  2. Why do the T lymphocytes attack the oligodendrocytes? And when they do, what is the mechanism for de-myelination?

Thank you in advance!

  • 4
    $\begingroup$ I'm voting to close this question as off-topic because it is better suited for Biology.SE $\endgroup$
    – AliceD
    Mar 26, 2015 at 12:44
  • $\begingroup$ Voted for deletion as it is answered on Bio: biology.stackexchange.com/questions/30242/… $\endgroup$
    – AliceD
    Apr 2, 2015 at 13:10


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