Microdialysis is a common method to study the effects of drugs on specific mamal brains zones (mostly in rats), in order to study the it's interaction with the function of those specific areas that controls or mediates in complex behavior.

There are invertebrates who are well known for providing genetic tools to study both behaviour and pharmacology of drugs, like c. elegans and Drosophila melanogaster. The last one has been also used for attention, learning and hyperactivity study, as a model for ADHD.

While I found a couple of studies which uses microdialysis on insect brains, I couldn't reach anyone for microdialysis in Drosophila. Is it possible to do microdialysis in Drosophila? Otherwise, there are alternatives to oral administration of drugs in insects like Drosophila?

-- Edit: Thanks for your insights, I have a computer science background and its hard to me to try to talk with property about these things completely out of my comfort zone. Also, I specified the original target, Drosophila Melanogaster, since there are bigger parients like Hawaian D. heteroneura and D. cyrtoloma. where current probes could be used """without too much trouble"""

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    $\begingroup$ @NickStauner I disagree, this is a common method in neuroscience. $\endgroup$ – Chuck Sherrington Aug 27 '14 at 7:59
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    $\begingroup$ (this page reads like an advertisement, but it is a good summary - psychogenics.com/microdialysis.html) $\endgroup$ – Chuck Sherrington Aug 27 '14 at 8:03
  • $\begingroup$ Thank you Chuck, I've found microdialysis probes with a membrane diameter of 240um , while the head of Drosophila must be around 200-300um , but I was wondering if the lack of microdialysis studies in Drosophila is just due to this technical constraint. $\endgroup$ – Keber Aug 27 '14 at 14:03
  • $\begingroup$ See the relevant meta-question: Are questions about neurobiology on or off topic? This debate is somewhat unresolved. We need your thoughts and votes! $\endgroup$ – Nick Stauner Aug 27 '14 at 18:11
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    $\begingroup$ Thanks @NickStauner, jona and Chuck, I made this question in Bio.SE (biology.stackexchange.com/q/20840/8992) and reddit, where I got a few hints. $\endgroup$ – Keber Aug 28 '14 at 12:54

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