Let me use Caffeine as an example for this question, because it's a classically understood case of drug tolerance.
Caffeine is an adenosine antagonist; it works by blocking the adenosine receptors in your brain, preventing adenosine from binding to them. Since adenosine has an inhibitory effect on the central nervous system, the effect is stimulation.
Your brain adapts to Caffeine pretty quickly by making more adenosine receptors, increasing the required dosage of Caffeine to get the same effect. Of course this means if you stop Caffeine, you will be absorbing more adenosine than baseline before Caffeine, because of all the new adenosine receptors. Over time off Caffeine, your body removes the excess adenosine receptors until you're back to normal.
My Question: Can you hack this process in reverse? Instead of taking an adenosine antagonist, say you took adenosine itself for some period of time. Following the same logic, would your body adapt by removing adenosine receptors below normal baseline? And then when you stop adenosine, would your "withdrawal" symptoms be a caffeine-like stimulation?