I have been googling and couldn't find the answer to these questions.

  1. For a given synapse, can a post-synaptic neuron have multiple types of receptors for different neurotransmitters or is typically just one type of receptor for a given synapse?

  2. For a given post-synaptic neuron, comparing across its dendrite synapses, can it have multiple types of receptors across different synapses or is it typically just one type of receptor for a given neuron?

  3. Do the quantity and types of receptors on a neuron change over time?

Thank you - much appreciated.


1 Answer 1

  1. One synapse can have different types of receptors for the same neurotransmitter (NT) (example: Glutamate - most glutamatergic synapses have both AMPA and NMDA types of receptors). Synapses can also have receptors for different neurotransmitters (see link).
  2. One neuron can also have different types of synapses which operate with different NT. An example of that would be shunting inhibition, when first comes excitatory synapse (NT - Glu), which depolarizes the membrane, but AP propagation is stopped by the inhibitory synapse (NT - GABA) which comes later. see picture

Hope it helps, I am also just a beginner :)


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