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I know people who can instantaneously remember many events from 50 years ago. Moreover, there are savants who have memorized thousands of books and can instantly read off paragraphs from any page of these books, what is the molecular mechanism of long term memory storage that satisfied two competing requirements:

  1. Instantaneous retrieval
  2. Stable long term storage

I see that there are number of school of thoughts. C.R. Gallistel is of the opinion that plastic synapsis cannot account for storage 1. He argues for storage in the cellular matter akin to DNA. I am looking for comprehensive and up to date readings on this topic.

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    $\begingroup$ Welcome. The molecular mechanism... Even at the macroscopic structural level this answer can fill libraries. Can you narrow down the question? You can give more focus to your question best by adding your own background research you've done so far and telling us where your search stranded. $\endgroup$ – AliceD Dec 16 '20 at 8:34
  • $\begingroup$ I have added more details. I am not an expert in the field. I am a computer scientist. If you are aware of specific topics in this question, then please share references. I will read them and improve my question. $\endgroup$ – sidharth chhabra Dec 18 '20 at 13:09
  • $\begingroup$ Remember that there are plenty of AI applications done with neural networks that only rely on weights between neurons to "remember" things. You'd have to buy various "efficiency" arguments that that is not enough for real brains and that one needs some intra-neuron coding of things like numbers (from the external world). Furthermore, you'd have to buy that that is the main mechanism, $\endgroup$ – Fizz Dec 19 '20 at 6:07
  • $\begingroup$ If you look at en.wikipedia.org/wiki/Encoding_(memory)#Molecular_Perspective it doesn't even mention such edgy theories, only the molecular mechanisms for LTP etc. $\endgroup$ – Fizz Dec 19 '20 at 6:10
  • $\begingroup$ Galistel's similar paper in RTSB is labelled an "opinion piece". royalsocietypublishing.org/doi/pdf/10.1098/rstb.2017.0119 And if you look at the pdf version of his paper in Trends (that you've linked to), it's also labelled "Opinion". $\endgroup$ – Fizz Dec 19 '20 at 6:16

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