Activity in the neocortex of the brain is significantly reduced during slow wave sleep. The general theory is that during that during this period of time memory consolidation occurs. Individuals with type 1 narcolepsy generally fail to enter slow wave sleep. Which presumably indicates that their neocortex operates continuously throughout the entire sleep-wake cycle. I suppose that is the basis for memory difficulties attributed to the narcoleptic condition. On the other hand, when a neuron is potentiated for a certain amount of time it enters that state of long term potentiation. Long term potentiation is critical for neuroplasticity of which is a mechanism for learning. Thereby could we assume that the neocortex of narcoleptic brain Remains in a more plastic state than a normal brain and if so should that not offset the memory consolidation decrepency?

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    $\begingroup$ I think you are using some non standard meanings of "depressed" in this context. Can you cite some supportive literature that you are using to make your assumptions? $\endgroup$
    – Bryan Krause
    Jan 18 '20 at 18:31
  • $\begingroup$ I don't have an answer, but a complication. While typically pre and post synaptic activity is required for Hebbian synaptic plasticity, plasticity also heavily depends on neuromodulators. I'm not sure how they are changed with narcolepsy. During Slow wave sleep there are also specific acitivity patterns that are thought to induce plasticity (google the rodent literature), these might also be affected. $\endgroup$
    – cosine
    Jan 21 '20 at 10:11

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