The following quote from the discussion in a review paper by Higley and Sabatini:
Finally, several studies demonstrate the ability of dendritic Ca transients to herald near-synchronous and spatially clustered synaptic activation. However, most of this evidence has been acquired in brain slices using forms of synaptic activation that may not closely resemble in vivo conditions. The intact brain is awash with robust and behaviorally context-specific patterns of synchronous neuronal activity (Buzsaki and Draguhn, 2004; Llina´ s and Steriade, 2006; Stevens and Zador, 1998).
Moreover, neurons in vivo are influenced by both excitatory and inhibitory synaptic connections as well as state-dependent actions of myriad neuromodulators.
Higley, M.J. and Sabatini, B.L., 2008. Calcium signaling in dendrites and spines: practical and functional considerations. Neuron, 59(6), pp.902-913.
made me pondering about the following questions:
- What's the difference between Calcium signal into the spine versus "Ca transients"?
- How do different neurons/spines have a coupled/correlated calcium signal?