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When two neurons connect to form a synapse, between the pre-synaptic and post-synaptic cells some space is found (synaptic cleft). How does this keep in position if there is no physical connection between the two?

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There is a physical connection.

Synapses are held together by adhesion molecules, like cadherins and neuroligins/neurexins.

Missler, M., Südhof, T. C., & Biederer, T. (2012). Synaptic cell adhesion. Cold Spring Harbor perspectives in biology, 4(4), a005694.

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