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I have a friend who experienced a cannabis induced psychosis about 5 years ago. He was on seroquel for about 4 years. However, since seroquel caused intense side effects, he decided to stop it cold turkey 8 months ago. At first he had very bad symptoms, which got weaker and weaker for 4 months. However, after 8 months abstinence, his psychotic symptoms returned in full force.

Why would the return of the psychotic symptoms take 8 months to return after abstinence from the drug? What does that tell us?

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  • $\begingroup$ What you saw is actually pretty typical. There aren't many studies on this, but one that was conducted found that "Mean time to exacerbation or relapse [after discontinuing anti-psychotics] was 235 days", Why it works like this isn't well understood as far as I know. $\endgroup$
    – Fizz
    Sep 12 '18 at 17:51

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