I was involved in a discussion where somebody had asked if others had thoughts of doing risky things during their manic episodes. Two people commented, including myself. I worried that only relying on a specific set of guidelines established by the diagnostic and Statistical Manual on Mental Disorders fifth edition could lead to disastrous consequences.

Let's say somebody came into a psychiatrist's office. The person has previously read the DSMV and understands the criteria. That person played their cards right to convince the psychiatrist to diagnose them with Bipolar Disorder, when in truth that person might not likely have it at all. Instead, their true motive would have been to get free benzos so they could space out and get high.

On the other end of the spectrum, some people have been misdiagnosed, leading to unwanted and unnecessary medications.

For both of these situations, why can't blood tests and other physical and objective means be used to insure that neither party is in doubt? You can't lie on a blood test or magneto encephalogram, so why not this?

  • $\begingroup$ because there are no objective biomarkers for bipolar disorder. $\endgroup$
    – honi
    Apr 27, 2018 at 3:08
  • $\begingroup$ I know, but why isn't one being developed? That's what this question is asking. There's got to be some hidden biomarker. $\endgroup$ Apr 27, 2018 at 6:15
  • $\begingroup$ Free benzos? More likely a prescription for valproate, which is more or less the same thing as sniffing paint thinner. I think you're confusing mania with anxiety... $\endgroup$ Apr 28, 2018 at 1:24

4 Answers 4


Short Answer

Science is hard, brains are complicated, and the premises of your question that there is not work being done or advancements in this area is false.

Longer Answer

There is no known specific cause of bipolar disorder (as for many other psychological disorders). There is no simple statement like "bipolar disorder happens when you are low on XYZ so let's test for XYZ." Bipolar disorder and many others are in fact defined by the DSM based on symptoms - diagnosing them in another way is not the gold standard.

That said, you seem to be implying especially in your comment "why isn't one being developed" that this isn't an active area of research. It is - a helpful search term for you will be 'biomarker'; Google Scholar returns 4,480 results since 2017 for ("bipolar disorder" "biomarker").

However, all of the suggested biomarkers are some combination of A) Not specific (i.e., are positive for other conditions), B) Not sensitive (i.e., are negative for people that do have bipolar disorder), C) Expensive or invasive (i.e., not really worth doing if they have issues with A and B), or highly dependent on other individual factors.


Because it's not as easy at it may seem. There is no direct biological distinguishment of any kind in such a case. It's like some prefer red, some prefer blue, some like both equally.

In order to link this condition to any bio-chemical causes, very long term studies would be needed and the persons with Bipolar Disorder will likely not volunteer for such studies.

It is not excluded that a very long term study may find a bio-chemical distinguishment unique to these individuals but that did not happened yet.

Related references (There are probably hundreds of references. Here's a few):

  • $\begingroup$ Welcome and thanks for your answer. Could you please provide us with your sources for the claims made in the 2nd and 3rd paragraphs? This allows other users to background read on your material. $\endgroup$ May 2, 2018 at 13:22
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    $\begingroup$ i have added some references. It would be nice to find a study that can centralize many of the findings. That way common markers could be found way more easy. $\endgroup$
    – Overmind
    May 3, 2018 at 13:05
  • $\begingroup$ Thank you so much for adding references. This is an awesome answer. $\endgroup$
    – Seanny123
    May 4, 2018 at 15:04

I could be wrong, since I'm not a doctor and all, but it's my understanding based on about ten years of studying issues like bipolar disorder online that to be diagnosed with bipolar disorder, as well as other disorders, like OCD, people merely need to have a set of symptoms, which disrupt their lives sufficiently, which hopefully respond to certain kinds of treatment (and of course, they probably need to be diagnosed in order for them to officially have it). This, as opposed to a specific physiological and/or genetic condition that causes or might cause the symptoms. It's not like strep throat where you can test for bacteria for a definitive diagnosis. There could be infinite causes of bipolar disorder as I understand it.

Thus, any tests that could diagnose it might miss a plethora of cases, and many of the people diagnosed by those tests might manage their condition perfectly already (which means they don't have bipolar disorder).

It's my understanding that the aim of such tests would be to assist doctors in making a good diagnosis rather than to replace the doctor's decision.

Nevertheless, there could be other conditions with symptoms similar to bipolar disorder, which do have a definitive underlying cause: e.g. vitamin B12 deficiency. I guess it's probably up to the doctor to decide if the individual also has bipolar disorder.

Anyway, I'm not saying bipolar disorder is all in one's head. At least some of the symptoms are physiological (such as how patients tend to get more manic if they take anti-depressants). I'm sure a lot of doctors use that criteria to help them diagnose the condition already. While I don't know another condition that would match that issue, it's possible there is one. However, just because symptoms are physiological doesn't mean they always have the same cause, which means they could have different methods of diagnosis.

Now, all that being said, while I still think a definitive test is possible, a new way of testing would perhaps be needed. A blood test isn't going to tell you behaviors or how well a person is managing their symptoms, or if the person is using good coping mechanisms that might cause them to not need a diagnosis. A blood test may tell you things that predispose people to behaviors and symptoms, however.

I wrote this answer before I read Bryan Crause's (I just read it). So, sorry that I repeated some of it.

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    $\begingroup$ Welcome and thanks for your interesting answer. It's perfectly fine to write a second answer with a bit of overlap. Could you provide us with your sources to allow other users to background read on your material? $\endgroup$
    – AliceD
    Apr 28, 2018 at 15:20

From https://neurosciencenews.com/depression-bipolar-blood-test-18197/:

A new blood test can distinguish the severity of a person’s depression and their risk for developing severe depression at a later point. The test can also determine if a person is at risk for developing bipolar disorder. Researchers say the blood test can also assist in tailoring individual options for therapeutic interventions.


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