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Let us consider the following clinical vignette:

A 61 y/o male presents complaining of migraines on the order of 2 or 3 times a month. When he gets them, the only thing that helps to mitigate them is a combination of Sumatriptan 100mg and Tramadol 37.5/325 . Given the patient's background, He asks you "I was hoping to commence treatment with an SNRI like Effexor or Cymbalta but I am concerned about Serotonin Syndrome when I get a migraine."

Based on best practice and current evidence, how legitimate are the patient's concerns?

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closed as off-topic by Arnon Weinberg, AliceD Mar 11 '18 at 22:59

This question appears to be off-topic. The users who voted to close gave this specific reason:

  • "Questions about the behavior of an individual person are off-topic. If you are concerned about a potential medical issue, please seek the advice of a medical professional. For more information, see Why was my self-help question closed as off-topic?." – Arnon Weinberg, AliceD
If this question can be reworded to fit the rules in the help center, please edit the question.