It seems intuitive to me that there is some kind of stress when one is put in an unfamiliar place (There's probably effect on cognitive abilities too). However, I can't find any paper in psychology which discusses that potential relationship.
I have found the following
I also found:
Padilla, A. M., Alvarez, M., & Lindholm, K. J. (1986). Generational status and personality factors as predictors of stress in students. Hispanic Journal of Behavioral Sciences, 8(3), 275-288.
stressful events center on loss of familial and cultural ties as well as on relative discomfort in an unfamiliar social environment
Lewis M. J. & Phillips J. E. (2012). Older people's cardiac responses as indicators of stress in familiar and unfamiliar environments. Psychophysiology, 49(4): pp. 478-483
DOI: 10.1111/j.1469-8986.2011.01321.x PMID: 22176515
You may be interested in related research on how unfamiliar environments negatively affect sleep quality.