As noted in a previous question, hallucinogenics, such as psilocybin, have been used to treat depression with some success. Chronic pain is affected somewhat by a top-down process from the brain, as shown in neurofeedback treatment via EEG. Have hallucinogenics been shown to be an effective treatment for chronic pain?


According to the National Institute for Drug Abuse

Some hallucinogens interfere with the action of the brain chemical serotonin, which regulates:

  • mood
  • sensory perception
  • sleep
  • hunger
  • body temperature
  • sexual behavior
  • muscle control

Other hallucinogens interfere with the action of the brain chemical glutamate, which regulates:

  • pain perception
  • responses to the environment
  • emotion
  • learning and memory

Morphine is a hallucinogenic and

Morphine is used to treat chronic pain

The NHS has also provided proof with links to articles that opiates are useful for chronic pain

Other hallucinogenics known to help with pain include Peyote (unreferenced)


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