I am interested in looking at the effects of too much BDNF and other proteins such as repressor element one silencing transcription factor (REST). Most research suggest that elevated levels are protective, however there is a small amount of research suggesting that too much (over expression) may actually be detrimental (Cunha, et al. 2009).

Our results demonstrate that chronic BDNF overexpression in the central nervous system (CNS) causes learning deficits and short-term memory impairments, both in spatial and instrumental learning tasks. This observation suggests that a widespread increase in BDNF in forebrain networks may result in adverse effects on learning and memory formation.

I was wondering if there is any more research, or theories as to why too much of a protein that is considered to be protective could be harmful? Thank you.


Cunha, C., et al. (2009) Brain-derived neurotrophic factor (BDNF) overexpression in the forebrain results in learning and memory impairments. Neurobiology of Disease, 33(3), pp. 358—368
DOI: 10.1016/j.nbd.2008.11.004


Because the too high expression will cause to lose specificity in the process of neural plasticity because it would make synapses too easy to make. Synapses that didn't should be made. The trkb receptor will exist in lower ammounts too, it is a protective mechanism, I think. The last thing that I can think it is the too easy LTP, that is stimulated by BDNF itself by interaction of TRKB with NA+ pumps

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