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Is there a difference in speed of impulses created by excitatory and inhibitory neurons?

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  • $\begingroup$ It is possible that they are different since the ion channels expressed in different cell types are different. I do not know of any studies though. $\endgroup$
    – Memming
    Jan 27, 2017 at 3:22

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There is a wide variety of inhibitory neuron classes. See here for a review of interneurons in the hippocampus: P. Somogyi, T. Klausberger, J. Physiol. 562, 9–26 (2005)..

Different classes of interneurons have different spike durations (e.g. "fast-spiking" or FS cells, generally used as a marker of putative PV+ interneurons). Additionally, different classes of interneurons have different post-synaptic receptors with specific temporal and other characteristics. For example, GABA-A receptors have time constants of ~10ms, whereas GABA-B receptors have time constants of ~100ms (and yes, there are subtypes of those receptor classes). You can see a modeling paper I wrote for exploration of a use for different receptor classes, as well as more references for further research. H. Sanders, M. Berends, G. Major, M. S. Goldman, J. E. Lisman, J. Neurosci. 33, 424–429 (2013)..

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