Lulu Xie et al write in their paper Sleep Drives Metabolite Clearance from the Adult Brain:

Using real-time assessments of tetramethylammonium diffusion and two-photon imaging in live mice, we show that natural sleep or anesthesia are associated with a 60% increase in the interstitial space, resulting in a striking increase in convective exchange of cerebrospinal fluid with interstitial fluid. In turn, convective fluxes of interstitial fluid increased the rate of β-amyloid clearance during sleep.

Given that Alzheimer's patients have more β-amyloid in their brains, do they also have less interstitial space?

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    $\begingroup$ I think the biology SE is better suited for this question $\endgroup$ – awakenting Aug 4 '16 at 12:54

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