I am learning how to use SPM and ISAS to analyze ictal and interictal SPECT. However I am stuck at a point of their tutorial.

In the item 1.2 one has to set the origin for the SPECT image. That is, to pinpoint the anterior commissure. This is a fairly easy task in a MRI, but very hard to do in a SPECT. How am I to find a tiny anatomical area in such a blurry image (like the one below)?

enter image description here

Are there any anatomical references that I should be using in order to find the approximate area for the anterior commissure?

Any help would be greatly appreciated.


1 Answer 1


You can use the Whole Brain Atlas by Harvard to look at the normal brain anatomy in 3-D with MRI/PET.

Check the Anterior Commissure (AC) on the MRI and sync it with the PET or SPECT. It helps.

More specifically, select "Anterior Commissure" and T1/FDG and click sync to show all the orientations in the same modalities and anatomical structure. It helps to find the anterior commissure in a normal brain using nuclear medicine image.

  • $\begingroup$ Thanks, Henrique, however I want to find the anatomical point of interest in the particular image I have in hand. Usually it does not comes with an anatomical image overlayed, and it is really hard to pinpoint the anterior comissure. I guess the answer is that one can never exactly find the anterior comissure when all one has is the SPECT image, w/o the anatomical image to guide... Thanks anyways... $\endgroup$
    – lf_araujo
    Aug 13, 2016 at 7:05

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