I've recently read the following folk parable and am interested if there is any truth to it.

It is originally in russian(full version here), so I will translate the gist of it:

The devil displays his Arsenal of tools used to corrupt mortals - anger, jealousy, greed, etc. Then he shows the "special" tool which can work when all else fails- depression (dismay or broken spirit). He suggests that once depression takes hold, the mind is open to all other tools (jealousy, greed, etc)

This got me thinking - is there some equivalent of a mental "immune system" which keeps the mind healthy and keeps negative, unwanted, maladaptive emotions at bay?

Are there conditions that make the mind more open to other disorders?

  • $\begingroup$ You mean other than dopamine et al.? $\endgroup$
    – Izhaki
    Commented Dec 10, 2015 at 23:20
  • $\begingroup$ Not sure what you mean by dopamine - specific sensitivity to it? Receptor mutations? $\endgroup$
    – Alex Stone
    Commented Dec 11, 2015 at 1:26
  • $\begingroup$ I mean the chemical agents affecting our emotions. $\endgroup$
    – Izhaki
    Commented Dec 11, 2015 at 2:11
  • $\begingroup$ In Orthodox theology, including the Philokalia which is dominant in religious circles, there are said to be three "passions" that act, in modern terms, as gateway drugs to all that follow. Accept one of them and you open the door to all of them; reject them, and you close the door. $\endgroup$ Commented Nov 13, 2019 at 22:52

1 Answer 1


Daniel Gilbert actually coined a term called immune neglect (Gilbert et al., 1998), which describes a common bias in affective forecasting. The idea is that when we try to predict how we'll feel following a negative situation, we fail to take into account (i.e., we neglect) that our psychological "immune system" will kick in and return us to some neutral baseline. So we overestimate how bad we'll feel.

Indeed, the idea that we have some homeostatic mechanism(s) (or really, allostatic; Sterling, 2014) that brings us back to some baseline has been thrown around in psychology for a while (e.g., Forgas & Ciarrochi, 2002), but emerging theory is starting to take this idea seriously (e.g., Barrett & Simmons, 2015; Craig, 2003; Sterling, 2014; Sterling & Laughlin, 2015).

So to your main question: what kinds of states make us susceptible to other negative mental states? One answer is a negative prior (e.g., Beck, 1979; Huys, Daw, & Dayan, 2015), which shapes your predictions about the world. For example, if you grew up in a threatening environment, you might develop a prior that yields predictions that the world will be threatening. Indeed, you might even discount evidence against your predictions (i.e., that the world is not threatening).

This is actually considered adaptive--you're using your prior knowledge ("the world is/was threatening") to make predictions about the world ("the world will be threatening") and to guide how much you weight the errors in your predictions ("the world is not threatening"). After all, if you've only been exposed to threat, then it's good to be hypervigilant to more potential threat and hypovigilant to potential indications otherwise.

So--that's what happens in depression, for example. You get "stuck" in a negative state because your negative prior leads you to weight negative information more heavily (Garrett et al., 2014) and ignore "the full range of signals from many sources" (Sterling, 2014). If you fail to change your prior in accordance with new evidence, then you'll behave maladaptively and remain depressed.

I think my answer is slightly incoherent and not complete, and I think there's probably a whole lot more to explain…but I hope it gives you some idea of what's going on.

  • 1
    $\begingroup$ Great answer! It makes sense that a negative state would skew future perception (put on the opposite of rose colored glasses), making the person less trusting, more easily triggered into jealousy, envy, greed and other vices. Depression, being a persistent negative state would effectively apply this outlook to all incoming information. $\endgroup$
    – Alex Stone
    Commented Dec 14, 2015 at 3:59

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