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How are the effects of drugs in the brain, in terms of neurotransmitters measured? For example, Selective Seretonin Reuptake Inhibitors are a class of anti-depressants. How was and is this type of information about hor neurotransmitters act obtained?

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  • $\begingroup$ It is unclear what you're asking. $\endgroup$ – jona Nov 11 '15 at 13:39
  • $\begingroup$ I mean what tools or techniques are used to measure these types of things? Like if a drug releases dopamine, it's not just a wild guess there must have been a way to come to that conclusion. To know which receptors it activates and all that. $\endgroup$ – Chris Nov 11 '15 at 14:10
  • $\begingroup$ I spent like 10min looking around on google and couldn't find anything. Then came here. $\endgroup$ – Chris Nov 11 '15 at 14:11
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    $\begingroup$ I'd recommend this previous answer which, I think, answers most of your questions. Surprisingly, many drugs are discovered by accident and their mechanisms are often worked out in the lab, or in animals, rather than in vivo. cogsci.stackexchange.com/questions/1748/… $\endgroup$ – splint Nov 12 '15 at 10:03
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    $\begingroup$ look up "microdialysis" $\endgroup$ – honi Nov 16 '15 at 1:49

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