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I wanted to know what a suitable classical conditioning experiment would be to analyze learning and memory capabilities in rodent models with respect to hippocampal long-term potentiation (LTP).

For example, I want to subject the animal to conditioning and test the behavioral readout at a certain time point after conditioning. Many , like fear conditioning experiments, are mostly attributed to amygdala processes.

I wish to know some classical conditioning task where I can understand primarily hippocampal processes.

Also is there a way to monitor hippocampal CA1-CA3 firing pattern after the training period or during the training ?

That is, I want to check if LTP will sustain after the training period or is there is any increased sustenance of LTP post training.

But if I am to do this electrophysiological experiment in hippocampal brain slices, how will I incorporate the conditioned and unconditioned aspect to this ?

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Read this paper

Storage of Spatial Information by the Maintenance Mechanism of LTP

Eva Pastalkova*, Peter Serrano*, Deana Pinkhasova, Emma Wallace, André Antonio Fenton†, Todd Charlton Sacktor† http://www.sciencemag.org/content/313/5790/1141.short

It uses a conditioning task that is primarily hippocampal as it is a spatial navigation task. They monitor the strength of CA3-CA1 connections during and after training using the fEPSP (field excitatory post-synaptic potential) slope.

Also, for a review of hippocampal dependent tasks, see

The role of hippocampal subregions in memory for stimulus associations

Rosamund F. Langston, Cassie H. Stevenson, Claire L. Wilson, Ian Saunder, Emma R. Wood

http://www.sciencedirect.com/science/article/pii/S0166432810004857

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