How many trials do you have per condition? With a small number of trials in the deviant condition, and a small number of participants, these things can happen.
The ISI would not cause this per se, however, have you considered looking at effects of the previous trial? You can analyze the baseline intervals as a function of what type the previous trial was, and see if there is a difference in the period following deviants or standards.
You could also try to randomly sample as many standard trials as you have deviants per participant, and then re-do your analysis and see what happens. You can make a loop and do this many times, and then look at the median p-value.
It could also be that some small number of subjects is introducing some skew to your results. You could try to re-do your analysis on a single subject level, comparing standard and deviant trials within subjects. Then you could see whether all your subjects have this effect or only some of them. If it's only some, you could look at their data more carefully for potential outliers. If it's a general thing, I'd look into the effects of the previous trial.
And if it's the previous trial effect, you can just remove all standard trials preceded by a deviant and try again.
All that being said, even if you have a baseline difference, it might not really matter: this is what baseline correction is for. But I agree that it's disconcerting.
I'm also a bit confused why you would use an ANOVA to compare two conditions, and not a t-test. Maybe I'm not understanding you design completely.